老年非糖尿病者糖化血红蛋白与脉搏波速度相关性分析  

Relationship between glycosylated hemoglobin and pulse wave velocity in non-diabetic elderly people

作　　者：张晏[1] 杨书文[1] 付静[1] 宋悦华[2] 马兰军[2] 朱玲[2] 

机构地区：[1]卫生部北京医院特需医疗部,100730 [2]卫生部北京医院体检中心,100730

出　　处：《中华老年医学杂志》2012年第12期1041-1043,共3页Chinese Journal of Geriatrics

基　　金：国家自然科学基金资助项目（（2-140406）

摘　　要：目的探讨老年非糖尿病者糖化血红蛋白（HbAlc）与脉搏波速度（PwV）的相关性。方法选取于我院查体的163例老年查体者（排除肝、肾功能不全、糖尿病及恶性肿瘤患者），依据HbAlc数值分为HbAlc〈5．7％组（A组）和HbAlc位于5．7％～6．4％之间组（B组），对两组人群年龄、体质指数（BMI）、PWV、收缩压、舒张压、血尿酸、血肌酐、血尿素氮、血总胆固醇（TC）、血三酰甘油（TG）、血低密度脂蛋白胆固醇（LDL—c）、血高密度脂蛋白胆固醇（HDL-c）以及是否患有高血压的人数比例进行比较，并对各相关指标与PwV的相关性进行多因素分析。结果A组共54例，B组109例，两组老年人除收缩压外，年龄、性别、高血压人数比例、PwV、BMI、舒张压、血尿素、血肌酐、尿酸、TC、TG、LDL-C、HDL-C差异无统计学意义（均P〈0．05）。多元逐步线性回归分析显示，以aA=0．10、aⅢ-0．10为筛选变量的标准，在老年非糖尿病者中，PWV与年龄、是否患有高血压、HbAlC呈正相关（口值分别为20．382、144．061、93．195，均P〈0．10）。结论老年非糖尿病者中HbAlc与动脉僵硬度相关，可作为老年人心脑血管疾病预测及管理的指标。Objective To explore the relationship between glycosylated hemoglobin and pulse wave velocity in non-diabetic elderly people. Methods Totally 163 subjects were included after exclusion of liver or kidney disfunction, diabetes mellitus or malignant tumor. They were divided into two groups., group A （HbAle%5.7%） （n=54） and group B （HbAlc 5.7%-6.4~）（n=109）. The age, pulse wave velocity, systolic blood pressure, diastolic blood pressure, blood chemistry and hypertension were compared between the two groups. Multi factor analyse was conducted to analyze the relative factors for pulse wave velocity. Results Systolic blood pressure was higher in group B than in group A （P % 0.05）. Multi-linear stepwise regression analyses suggested that age, hypertension, glycosylated hemoglobin were positively related to pulse wave velocity in non-diabetic elderly people （t3 values were 20. 382, 144. 061, 93. 195, all P^0. 10）. Conclusions Glycosylated hemoglobin is related to arterial stiffness in non-diabetic elderly people, it can be used as a predictive and control target of cardiovascular and cerebrovaseular disease in old people.

关 键 词：血红蛋白A 糖基化 脉搏 

分 类 号：R587.1[医药卫生—内分泌]