异佛司可林和佛司可林对兔高眼压模型的降眼压作用  

Suppressing effect of isoforskolin and forskolin on ocular hypertension in rabbits

作　　者：李新华[1] 聂玲辉[2] 杨为民[1] 陈植和[1] 王新华[1] 罗礼宏 

机构地区：[1]昆明医学院云南省天然药物药理实验室,650031 [2]昆明医学院第二附属医院眼科

出　　处：《中华眼科杂志》2000年第4期292-294,共3页Chinese Journal of Ophthalmology

摘　　要：目的　探讨异佛司可林 (isoforskolin ,isoF)和佛司可林 (forskolin ,FSK)悬液滴眼对眼压增高 (ocularhypertention ,OHT)的作用 ,并观察药物的局部剌激性。方法　选用自发 (11只 )和水负荷 (36只 )OHT兔 ,以气动式眼压计测量眼压 ,并评价药物作用 ,同时记录剌激性反应。结果　在自发OHT兔 ,isoF悬液滴眼后 0 5～ 4 5h眼压显著性降低 (配对t检验 ,与对照眼比较P <0 0 5 ) ,其中 0 2 5 %和1%isoF在滴眼 1 5h后作用最明显 ,分别降低 8 1和 7 0mmHg(1mmHg =0 133kPa)。在水负荷OHT兔 ,0 0 6 %、0 1%、0 2 5 %、1%isoF和 0 2 5 %、1%FSK均呈剂量依赖性地抑制水负荷引起的眼压升高(除 0 0 6 %isoF外 ,P <0 0 5 ) ,最佳浓度 0 2 5 %isoF和 1%FSK的峰值效应两侧眼眼压差值为 7 1mmHg和 6 9mmHg。实验还显示 ,0 2 5 %isoF和FSK悬液基本无刺激性 ,而 1%浓度时有轻度剌激反应。结论　isoF和FSK均能抑制兔的OHT ,最佳效应浓度分别为 0 2 5 %和 1% ;两药在 0 2 5 %浓度基本无表面剌激 ,而Objective To examine the effects of isoforskolin (isoF) and forskolin (FSK) suspensions administered topically on eyes with ocular hypertension (OHT) and observe the local irritation of the drugs Methods The intraocular pressure (IOP) was measured with pneumotonometer in screened spontaneous or water loading induced OHT rabbits for evaluation of drug effects, and the irritation indices were recorded as well Results In screened OHT rabbits, isoF significantly lowered IOP from 0 5 to at least 4 5 h after the administration ( P <0 05, paired t test vs contralateral control eyes), with the maximum decreases of 0 25% and 1% isoF reaching 8 1 mm Hg and 7 0 mm Hg (1 mm Hg=0 133 kPa) at about 1 5 h later, respectively In water loaded OHT rabbits, both 0 06%, 0 1%, 0 25%, 1% isoF and 1%FSK concentration dependently suppressed the increments of IOP ( P <0 05 with the exception of 0 06% isoF) induced by water loading, and the peak effects of the optimal concentration of 0 25% isoF and 1% FSK were 7 1 and 6 9 mm Hg (difference of IOP between bilateral eyes) respectively The results also indicated that 0 25% isoF or FSK suspension had basically no irritation, but 1% induced slight irritating responses during the experiment Conclusion Both isoF and FSK had suppressing effects on OHT in rabbits with the optimal concentration being 0 25% and 1% respectively; at concentration of 0 25%, topically both drugs had basically no irritation, while 1% of the drugs may induce mild irritating responses

关 键 词：异佛司可林 佛司可林 兔 高眼压 

分 类 号：R965[医药卫生—药理学]