4种引起慢性感染的肝炎相关病毒的流行病学研究  

Epidemiological study on four hepatitis related viruses associated with chronic infections

作　　者：陈青[1] 彭晓谋[1] 高志良[1] 陈雪娟[1] 黄仰苏[1] 姚集鲁[1] 

机构地区：[1]中山医科大学附属第三医院传染科,510630

出　　处：《广东医学》2000年第7期551-553,共3页Guangdong Medical Journal

基　　金：广东省自然基金项目!(编号 :970 0 79);中山医科大学"2 1 1工程"项目!(编号:98014)

摘　　要：目的　了解HBV ,HCV ,HGV和TTV等 4种病毒在当前预防模式下的流行情况。方法　收集 9种人群共 616份的血清标本 ,采用EIA检测 4种病毒的抗原或抗体 ,PCR方法检测 4种病毒的核酸 ,并进行纵向与横向比较分析。结果　HBV ,HCV ,HGV和TTV在健康人群中均能检出 ,现行感染率分别为 13 3 % ,0 8% ,0 8%和 2 5 %。在献血员和骨髓移植供体人群中 ,未检出HBV现行感染和HCV感染。在其他各人群中 ,除血液透析患者外 ,HBV总感染率和现行感染率均约高于HCV ,HGV和TTV相应感染率的 5～ 2 0倍。 47 6%急性肝炎由HBV感染引起 ,未发现急性丙型肝炎患者。在有肝功能损害人群中 ,HBV为主要感染病毒 ,其次为HCV ,而HGV和TTV则主要表现为其他肝炎病毒重叠感染。结论　HBV感染仍是各人群中主要流行病毒和引起肝功能损害的主要病原体 ,是今后肝炎病毒感染防治的重点。Objective To study the epidemiology of HBV, HCV, HGV and TTV under present prevention model. Methods EIA and PCR were used to detect viral markers in 616 sera from 9 populations. Results were compared analyzed among different viral types and population types. Results Current infection rate of HBV, HCV, HGV and TTV in healthy persons was 13 3%, 0 8%, 0 8% and 2 5% respectively. Non current HBV and HCV infections were found in blood donors and bone-marrow donors. Both the total infection rate and current infection rate of HBV were 5～20 times higher than those of HCV, HGV and TTV in the rest groups except for hemodialysis patients. 47.6% acute hepatitis were found to be hepatitis B. There was no acute hepatitis C. HBV was the main pathogen, followed by HCV was the subsequent one, HGV and TTV were usually superinfected with HBV and/or HCV among the groups with liver dysfunction of the liver. Conclusion HCV infection is well prevented. HBV infection is not completely controlled yet. With the emergence of HGV and TTV discovers, HBV remained to be the main pathogen for liver diseases and should be emphasized in hepatitis prevention.

关 键 词：病毒性肝炎 肝炎病毒 流行病学 

分 类 号：R512.6[医药卫生—内科学]