兔前交叉韧带保残重建的生物力学研究  

Anterior cruciate ligament reconstruction with remnant preservation in rabbits： a biomechanical study

作　　者：宋关阳[1] 张晋[2] 李旭[2] 陈星佐[2] 李岳[2] 冯华[2] 

机构地区：[1]清华大学,北京100084 [2]北京积水潭医院运动损伤科

出　　处：《中华创伤骨科杂志》2012年第12期1037-1041,共5页Chinese Journal of Orthopaedic Trauma

基　　金：国家自然科学基金（81071485）

摘　　要：目的应用动物模型评估保留残端对兔前交义韧带（ACL）重建的生物力学意义。方法将50只成年健康新西兰大白兔一侧后肢制作ACL断裂模型后随机分为两组（n=25），一组行保留残端ACL晴建术（保残组），另一组行去除残端ACL重建术（去残组）。所有手术均采用自体半腱肌腱作为移植物，并于术后12周统一将两组动物处死，行ACL大体观察及生物力学测试。结果术后12周取材时，保残纰和去残组总计50个标本关节活动度与正常侧相比差异无统计学意义（t=0．440，P=0．662）。所有ACL移植物连续性完整，张力满意。保残组和去残组标本屈膝30°与90°胫骨前移距离、最大批力载荷、最大拉伸距离以及刚度所占正常侧百分比差异均无统计学意义（P〉0．05）；保残组中残端仃活组和残端失效组标本屈膝30°与90°胫骨前移距离、最大拉力载荷、最大拉伸距离以及刚度所占正常侧百分比差异均尤统计学意义（P〉0．05）。结论保留残端重建ACL不能硅著提高术晤兔ACL的牛物力学性能。Objective To evaluate the biomechanical stability of tile knee joint after rem- nant-preserved anterior erueiate ligament （ACL） reconstruction using a rabbit model. Methods Models of ACL rupture were created iu any one of tile hindlimbs of 50 mature female New Zealand white rabbits befi/re tile animals were randomly divided into 2 equal groups. Group 1 （ n = 25） were treated with remnant-preserved ACI, reconstruction using semitendinosus tendon autografts and group 2（ n = 25） with conventional ACL re- construction using semitemlinosus tendon atttografts. All animals were sacrificed at 12 weeks after surgery for macroscopic evaluations and biomechanical testing. Results Macroscopic observations revealed that there were no significant differences between the operated and normal hindlimbs regarding the rang of motion （ROM） / t = 0. 440, P = 0. 662） . All gecons/ructed ACLs mainlained adequate continuity and tension. The biome- chauical testing showed no significant differences between the 2 grot,ps with respect to the anterior translation at 30° and 90° of knee flexion, the elongation at failure and the ratio of the uhimate failure load and the stiffness compared to the normal side （ P 〉 0.05）. In group 1, the specimens of surviving remnant fibers had no signifi- cant biomeehanical differences from those of failed remnant fibers either with respect to the above indexes （ P 〉 0. 05）. Conclusion The remnant preservation technique may not significantly enhance the biomechanical performance of reconstructed ACL,; in rabbits.

关 键 词：前交叉韧带 膝损伤 关节镜 修复外科手术 生物力学 

分 类 号：R687.4[医药卫生—骨科学]