440例帕金森病患者非运动症状的发生率及相关因素分析  

Prevalence of non-motor symptoms in 440 patients with Parkinson＇s disease and theircorrelative factors

作　　者：马敬红[1] 邹海强[4] 孙菲[2] 安静 陈彪[1] 

机构地区：[1]首都医科大学宣武医院神经内科,北京100053 [2]社会医学部 [3]老年病研究所 [4]广州军区广州总医院神经内科,广州510010

出　　处：《中华神经医学杂志》2012年第12期1225-1228,共4页Chinese Journal of Neuromedicine

基　　金：国家高技术研究发展计划（863）资助项目（2006AA02A408）;国家重点基础研究发展计划（973）资助项目（2011CB504101）;科技部973计划重大科学问题导向项目（2011CBA00408）

摘　　要：目的探讨帕金森病（PD）患者非运动症状的发生率及其相关因素。方法连续选取自2008年1月至2011年12月北京宣武医院PD专科门诊确诊为原发性PD的440例患者，详细记录其起病年龄、病程等临床资料，选择非运动症状筛查量表、汉密尔顿抑郁量表（HAMD）及统一帕金森病评分量表（UPDRS）进行评分，并对相关数据进行统计学分析。结果440例PD患者中，排便不尽感和便秘发生率最高，分别为60．5％和60％，其次是记忆力下降（56．6％）、多汗（52％）和情绪低落（47．7％）。病程、HAMD总分、UPDRSⅡ和Ⅲ部分总分与非运动症状数量呈正相关关系（P〈0．05）。不同病程的患者白天流涎、味觉或嗅觉异常、吞咽困难或饮水呛咳、便秘等发生率差异有统计学意义（P〈0．05）。而记忆力注意力下降、情绪低落等的差异无统计学意义（P〈0．05）。结论胃肠道症状、记忆力及注意力下降、情绪障碍是PD最常见的非运动症状。病程越长、抑郁症状越重、病情越重。患者非运动症状的数量越多。Objective To investigate the prevalence of non-motor symptoms in patients withParkinson disease （PD） and their impact factors. Methods The detailed clinical information （onset age and disease duration） of 440 patients with idiopathic PD, admitted to our hospital from 2008 to 2011, were recorded. Several scales, including non-motor symptom screening scale, Hamilton depression rating scale （HAMD） and unified Parkinson＇s disease rating scale（UPDRS）, were performed; these data were calculated with SPSS statistic software. Results Among the 440 PD patients, defecation incompletion （60.5%） and constipation （60%） enjoyed the highest frequency, followed by forgetfulness （56.6%）, sweating （52%） and sadness （47.7%）. Spearman rank correlation analysis showed that the sum of non-motor symptoms had a linear positive correlation with disease durations, HAMD total scores, and UPDRS II and III scores （P〈0.05）. The frequency of daytime dribbling, taste/smelling abnormality, swallowing difficulty or choking, and constipation in patients with different disease durations were significantly different （P〈0.05）; however, the frequency of forgetfulness, concentration and sadness in patients with different disease durations showed no significant differences （P〉0.05）. Conclusion Gastrointestinal and psychiatric symptoms, and memory loss are the most common non-motor symptoms in PD patients; the sum of the non-motor symptoms increases with the increment of disease durations and the severity of PD and depression.

关 键 词：帕金森病 非运动症状 抑郁 

分 类 号：R742.5[医药卫生—神经病学与精神病学]