海水浸泡性胸部开放伤的实验模型建立及早期死亡原因探讨  

Experimental Model of Seawater Immersion arter Open Chest Injuryand Analysis of Risk Factors of Early Death

作　　者：李辉[1] 鹿尔驯[1] 虞积耀[1] 王育红[1] 孙笑非[1] 王大鹏[1] 周正谋[1] 关淑珍[2] 马聪[2] 李忠安[2] 

机构地区：[1]海军总医院胸外科 [2]海军总医院检验科

出　　处：《海军总医院学报》2000年第2期65-67,共3页Journal of Naval General Hospital of PLA

基　　金：本课题为解放军总后勤部卫生部"九五"指令性课题(96-L004)

摘　　要：目的:建立犬海水浸泡性胸部开放伤实验模型,探讨致伤机理及早期死亡原因.方法:20只成年杂犬随机分为2组.实验动物致伤后随机分为单纯胸外伤组(n=10)和海水浸泡组(n=10).海水浸泡组动物于伤后置入人工配制的海水中,实验中监测血液动力学、呼吸系统和动脉血气变化.结果:海水浸泡组死亡率明显高于单纯胸外伤组,并且生存时间明显短于单纯胸外伤组,平均生存时间为45min.结论;本实验模型致伤精度高,重复性好,创伤后造成的呼吸循环功能改变与胸部火器伤所见相符,适用于海水浸泡性胸外伤的早期病理生理研究.急性呼吸和循环功能衰竭以及严重酸中毒(代谢性+呼吸性)是早期死亡原因.Objective: To establish an experimental model of open chest injury and sea water immersion and to evaluate the risk factors of early death. Methods: Twenty health dogs were divided into two groups. A model of right open pneumothorax was established. Control group (n=10) was open pneumothorax only and experimental group (n=10) had seawater immersion after chest trauma. Blood samples were taken at eight different time intervals for assessing blood gas, serum osmotic pressure and serum electrolytes. The hemodynamic and respiratory changes were recorded. At the end of study lung was harvested for pathologic examination. Results.- Post-trauma mortality was much higher in experimental group than that in control group. Progressive dysfunction of respiratory and circulatory system, acute lung injury, severe hypernatrem-ia and higher osmotic pressure were found only in experimental group. The mean survival time in experimental group was 45 minutes. Conclusion: The model established in this study is applicable for physiopathologic study of open chest injury and seawater immersion. Seawater immersion after open pneumothorax could result in severe physiopathologic changes. These risk factors appear to be associated with early death in experimental models.

关 键 词：胸部创伤 海水浸泡 实验模型 死因 

分 类 号：R655[医药卫生—外科学]