碳基光热转换纳米材料的表面功能化和生物应用  

Surface Functionalization and Biological Application of Carbon-based Nanomaterials with Photothermal Effects

作　　者：陈志钢[1] 张丽莎[2] 田启威[1] 胡俊青[1] 

机构地区：[1]东华大学材料科学与工程学院纤维材料改性国家重点实验室,上海201620 [2]东华大学环境科学与工程学院,上海201620

出　　处：《材料导报》2012年第23期30-33,50,共5页Materials Reports

基　　金：国家自然科学基金(21107013;21171035;50902021;51272299);高等学校博士学科点专项科研基金(20090075120014;20110075120012);上海市青年科技启明星计划(11QA1400100);中央高校基本科研业务费专项资金;高等学校学科创新引智计划(111-2-04)

摘　　要：光热治疗技术已经引起了广泛的重视,其走向应用的前提是开发出高效稳定的光热转换材料。碳基光热转换纳米材料具有毒性小、稳定性高等优点,已经成为了研究的热点。综述了碳基光热转换纳米材料(包括纳米碳管和石墨烯)的研究进展,重点论述了其表面改性技术(包括非共价键改性和共价键改性方法);随后总结了其表面功能化方法,主要有RGD、抗体、叶酸和DNA等靶向性功能化的修饰方法;最后介绍了其在光热治疗、近红外热成像等生物医药方面的应用。Photothermal therapy technology is attracted much attention, and a prerequisite for the development of its biological applications is to obtain photothermal agents with excellent conversion efficiency and stability. Carbon- based photothermal agents is drawn increasing interest due to their advantages such as low toxicity and excellent sta- bility. The recent research progress in carbon-based nanomaterials with photothermal effects is reviewed, including carbon nanotube and graphene. The main attention is given to the advance in their surface modification technologies in- cluding non-covalent modification and covalent modification- Subsequently, the functionalization methods of carbon- based photothermal agents with RGD, antibody, folic acid and DNA are summarized. At last, their biological applica- tions, including photothermal ablation therapy and NIR photothermal imaging are introduced.

关 键 词：碳基纳米材料 光热转换 制备 表面功能化 生物应用 

分 类 号：O647.11[理学—物理化学] Q50[理学—化学]