两亲性温度及pH敏感性嵌段共聚物胶束的制备及其负载紫杉醇释放行为的研究  

Research on Preparation of Temperature/pH Sensitive Amphiphilic Block Copolymer and the Release Behavior of Its Load Paclitaxel

作　　者：郭莉[1] 景欢旺[2] 

机构地区：[1]青海大学化工学院,西宁810016 [2]兰州大学化学化工学院功能有机分子化学国家重点实验室,兰州730000

出　　处：《材料导报》2012年第24期70-76,共7页Materials Reports

摘　　要：采用可逆加成-断裂链转移自由基聚合法成功地制备了以聚甲基丙烯酸甲酯(PMMA)为疏水性内核,聚丙烯酸-b-聚异丙基丙烯酰胺(PAA-b-PNIPAM)为亲水性外壳的具有核-壳结构的两亲嵌段共聚物聚甲基丙烯酸甲酯-b-聚丙烯酸-co-聚异丙基丙烯酰胺(PMMA-b-(PAA-co-PNIPAM))。此嵌段共聚物以聚异丙基丙烯酰胺作为温度敏感段、以聚丙烯酸作为pH敏感段,具有温度、pH值双重敏感性。通过一系列测试分析,结果表明嵌段共聚物在水溶液中能够自组装形成直径为200nm的胶束颗粒。以嵌段共聚物PMMA-b-(PAA-co-PNIPAM)为载体,成功负载了抗癌药物紫杉醇(PTX),模拟了这种载药胶束在人体环境中的控释行为。结果表明载药胶束在人体正常生理温度(37℃)和病变温度(40℃)下的释放速率和累积释放量都要比室温(25℃)下大很多。此嵌段共聚物兼具温度、pH值双重敏感性,在药物缓释方面有潜在的应用前景。Poly（methyl methacrylate）-b-（poly（crylic acid）-b-poly（N-isopropylacrylamide）） （PMMA-b-（PAA co-PNIPAM）） which has a core-shell structure with the hydrophobic inner core （PMMA） and the hydrophilic shell （PNIPAM） was prepared by reversible addition-fragmentation transfer （RAFT） radical polymerization. The block co polymer （PMMA-b-（PAA-co-PNIPAM）） comprised PNIPAM as the Thermo-sensitive block and PAA as pH-sensirive block. The copolymers can undergo supramolecular self-assembly to thermo-response nanosized micelles inaqueous media. The micelles were regularly spherical in shape with an average hydrodynamic diameter around 200nm. The drug delivery behaviors of the embedding of this anti-cancer drug paclitaxel （PTX） micelles in a simulated human body environment were studied. The release speed and quantity of the micelles at natural body temperature （37℃） and malignant temperature （40℃） are more than that at 25℃. This block polymer have double sensitivity of temperature and pH, and it has a potential application prospect in the aspect of drug slow-release.

关 键 词：两亲性嵌段共聚物 胶束 紫杉醇 控释行为 

分 类 号：TQ311[化学工程—高聚物工业]