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作 者:傅希贤[1] 王勤环[1] 田庚善[1] 皇甫玉珊[2] 王兆荃[3] 王淑兰 郑文辉 张娴
机构地区:[1]北京医科大学第一医院,北京100034 [2]解放军第三○二医院,北京100039 [3]中国医科大学二院,沈阳110001 [4]徐州市鼓楼医院,徐州221000 [5]大连市第六医院,大连116000 [6]青岛市第六医院,青岛266033
出 处:《传染病信息》2000年第2期70-70,共1页Infectious Disease Information
摘 要:目的为了研证美国安进公司研制生产的重组复合干扰素,比较15μg和9μg干复津与11.1μg(3MU)罗扰素治疗慢性丙型肝炎的疗效和安全性。材料和方法 67例确诊为慢性丙型肝炎的患者,随机分为A组(干复津15μg)20例,B组(干复津9μg)23例,C组(罗扰素)24例。每周32次皮下注射连用24周,停药后继续观察24周。定期检查肝、肾功能、血象、凝血酶原时间、甲状腺功能、抗HCV和HCV-RNA。结果治疗24周时A、B、C三组的ALT复常率分别为75.0%、73.9%和58.3%,HCV-RNA阴转率分别为80.0%,73.7%和61.9%,显效率(ALT正常,HCV-RNA亦阴转者)三组分别为65.0%、57.9%和33.3%。A、C组间差异显著。48周时ALT正常率分别为70.0%、63.6%和70.8%,HCV-RNA阴性率则为75.0%、61.1%和71.4%,显效率分别为50.0%、44.4%和61.9%,但无统计学差异,引起的不良反应三组间亦无差异。结论 15μg和9μg的干复津为治疗慢性丙型肝炎是有效而且安全的药物。Objective To evaluate the efficacy and safety of consensus interferon (CIFN) in treatment of chronic hepatitis C. Methods A total of 67 patients with chronic hepatitis C were randomized to receive subcutaneous injection of 15μg CIFN (group A, n = 20), 9μg CIFN (group B. n = 23) and 3MU Roferon (group C, n = 24) respectively for 24 weeks and then observed for another 24 weeks. Results By the end of the treatment, the normalization rates of ALT were 75. 0%, 73. 9% and 58. 3% while the negative rates of HCV-RNA were 80. 0% , 73. 7% and 61. 9% respectively in groups A, B and C. The percentages of the patients with normal ALT and negative detection of HCV-RNA were 65. 0%, 57. 9% and 33. 3% in the three groups respectively. At the end of the observation, we got the following corresponding numbers in the three groups: 1) ALT normalization rates of 70.0%, 63. 6% and 70. 8%; 2) negative rates of HCV-RNA of 75.0%, 61. 1% and 71. 4% ; 3) percentages of the patients with normal ALT and negative detection of HCV-RNA of 50. 0%, 44. 4% and 61. 9%. Conclusion CIFN at the dosages of 15μg and 9μg is effective and safe for treating chronic hepatitis C.
分 类 号:R512.630.5[医药卫生—内科学]
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