雷莫司琼预防急诊剖宫产术中恶心呕吐的临床效果  

Efficacy of ramosetron in the prevention of postdelivery nausea and vomiting during emergency cesarean delivery

作　　者：李晓剑 陈霞 韩瑛[2] 

机构地区：[1]山西省大同市第一人民医院麻醉科,037004 [2]湖北医药学院附属太和医院细胞治疗中心

出　　处：《中华全科医师杂志》2012年第8期603-604,共2页Chinese Journal of General Practitioners

摘　　要：选择急诊剖宫产手术患者206例，随机分成2组：雷莫司琼组（钳夹脐带后静脉给予雷莫司琼0．3mg，103例），对照组（钳夹脐带后静脉给予等容量生理盐水，103例），分别观察并记录剖宫产娩出胎儿后恶心、呕吐的发生率，术中追加呕吐药的几率，低血压发生率，疼痛评分及其他不良反应发生率。雷莫司琼组患者恶心、呕吐发生率为10．7％（11例），对照组患者发生率为28．2％（29例），差异有统计学意义（P〈0．01），两组术中低血压比较差异无统计学意义（P〉0．05）。雷莫司琼能降低急诊剖宫产术中患者恶心呕吐发生率。We sought to determine the efficacy of ramosetron in the prevention of nausea and vomiting during emergency cesarean delivery under spinal anesthesia with strict controls of causative factors. A total of 206 parturients participated in a randomized, single-blind and plaeebo-controlled trial. They received an intravenous injection of either ramosetron 0. 3 mg or normal saline immediately after cord elamping. The primary outcome was the presence of postdelivery nausea and vomiting. Secondary outcomes included the need for rescue antiemetic, hypotension, pain and adverse effects. The incidence of postdelivery nausea and vomiting was 10. 7% in the ramosetrou group vs. 28.2% in the control group （P 〈 0. 01 ）. The incidence of intraoperative hypotension and postdelivery was similar in both groups. The incidence of postdelivery pain and the requirement for rescue antiemetic were similar in both groups. Ramosetron 0. 3 mg is effective in the prevention of postdelivery nausea and vomiting during cesarean delivery.

关 键 词：剖宫产术 产后呕吐 

分 类 号：R614[医药卫生—麻醉学]