高频喷射通气治疗PE-SWD兔血气和Na^+-K^+-ATPase图像分析定量研究  

Image and Quantity Analysis of Blood-Gas in Rabbit's Artery and Na^+-K^+-ATPase in Their Lungs During PE-SWD Treated by HFJV

作　　者：董敏[1] 丁勇[1] 张敏华[1] 骆云[1] 王琰[1] 刘虹[1] 董文度[1] 

机构地区：[1]海军医学高等专科学校病理教研室,南京210099

出　　处：《生物医学工程学杂志》2000年第2期183-185,191,共4页Journal of Biomedical Engineering

基　　金：中国人民解放军总后卫生部科研基金!96M036

摘　　要：为了探讨高频喷射通气（HFJV）治疗海水淹溺肺水肿（PE－SWD）的作用机理，采用全自动血气酸碱分析仪和计算机图像分析系统，对海水淹溺肺水肿组（PE－SWD－G）、高频喷射通气组（HFJV－G）和正常对照组（Con－trolgropu,CG）兔PaO2、p8CO2、血氧饱和度（SSO2）和兔肺内N+－K+－ATPase进行自动检测和定量分析。结果表明，PE－SWD经HFJV治疗100min后，HFJV－G中的PaO2、SaO2和肺毛细血管内皮细胞中Na+－K+－ATPase活性比PE－SWD－G明显升高（P＜0．01或P＜0．05），并且HFJV－G中Na+－K+－ATPase的3项参数（D1、D2和G6）几乎恢复到接近CG水平。HFJV－G兔PaO2和SaO2的升高与肺内Na+－K+－ATPase活性的恢复密切相关。HFJV对PESWD的治疗，关键在于能较好地纠正低氧血症，因而对肺内Na+－K+－ATPase的恢复有明显的促进作用。This study was made to gain an insight into the mechanism of high-frquency jet ventilation(HFJV)treatment for the pulmonary edema after seawater drowning (PE-SWD). PaO2, PaCO2 and oxygen saturation (SaO2) of the rabbit and Na+-K+-ATPase in the rabbit's lungs in three groups-PE-SWD group(PE-SWD-G),HFJV group (HFJV-G) and control group(CG), were measured and analysed by the blood-gas analyser and computer image system. The results showed that, after 100 minutes' HFJV, the PaO2, SaO2 and the activity of Na+-K+-ATPase in the lung capillary endothelial cells in HFJV-G were significantly higher than those in PE-SWD-G(P＜0.01 or P＜0.05). Three parameters of Na+-K+-TAPase(G1, D1 and D2) in HFJV-G almost returned to their values in CG. The authors suggest that the increase of PaO2 and SaO2 in the rabbit's artery blood in HFJV-G is closely related to the rehabilitation of Na+-K+-ATPase activity in the lungs after HFJV- the mechanism of successful HFJV treatment for PE-SWD is that HFJV can better correct hypoxemia and improve the rehabilitation of Na+-K+-ATPase activity in the rabbit's lungs.

关 键 词：高频喷射通气 海水淹溺肺水肿 血气 钠钾ATPase 

分 类 号：R459.6[医药卫生—治疗学]