肾脏疾病患者血清胱抑素C检测结果分析  

Test results analysis of serum cystatin C in patients with kidney disease

作　　者：陈映[1] 吴家梅[2] 

机构地区：[1]四川省什邡市人民医院,四川什邡618400 [2]资阳市第一人民医院,四川资阳641300

出　　处：《内蒙古中医药》2012年第19期F0002-F0002,180,共2页Inner Mongolia Journal of Traditional Chinese Medicine

摘　　要：目的:探讨血清胱抑素C Cystatin C(Cys C)对肾脏疾病的诊断价值。方法:留取患者24小时尿液测定内生肌酐清除率,同时测定胱抑素C、血清β2微球蛋白、血清肌酐、血清尿素氮的浓度,并按Ccr测定值的大小将患者分为4组,将各组生化指标比较。结果:Ccr≥80组各项生化指标与对照组比较无显著性差异(P>0.005),但Cys C和β2-MG已有增高倾向,而Ccr<80各组生化指标均不同程度增高,尤其是血清Cys C和β2-MG升高明显,与对照组比较差异显著(P<0.01)。结论:Cys C是目前肾小球滤过率变化最为理想的标志物,Cys C的检测方法简便、快捷、检验结果可靠,越来越多的研究证实Cys C在多各疾病领域得到应用,在肾脏疾病的诊断上具有重要价值。Objective：To discuss the diagnostic value of Cystatin C （Cys C） in treatment of renal disease. Method： Sample the pa-tient＇s 24h urine and determine endogenous creatinine clearance rate; in the meantime, determine the concentration of Cystatin C, serum β2 microglobulin （β2-MG）, serum creatinine （SCr）, and serum urea nitrogen （SUN）, then divide the patients into 4 groups on a basis of Cer measured value and compare these groups in biochemical indices. Result：The groups with Ccr≥80 had no signifi-cant difference with the control group in biochemical indices （P〉0. 005）, but Cys C and β2-MG had the tendency of increase. The groups with Ccr〈80 had significant difference with the control group （P〈0. 01）, for biochemical indices increased to different ex-tent, especially Cys C and β2-MG, both of wl,ich showed an obvious increase. Conclusion： At present, Cys C is the most ideal mark-er of variation of glomerular filtration rate, and it is easy, fast and convenient to determine, and the results are reliable; more and more studies have proved the application of Cys C in multiple diseases and its significant value in the diagnosis of renal diseases.

关 键 词：肾脏疾病 血清胱抑素C 内生肌酐清除率 肾小球过滤率 β2微球蛋 

分 类 号：R692[医药卫生—泌尿科学]