pH滴定法测定甲硝唑的含量  

Determination of metronidazole by pH titration method

作　　者：姜爽[1] 刘惠军[2] 吴宏斌[3] 

机构地区：[1]大连市二一0医院住院部药局,116021 [2]佳木斯市中心医院 [3]佳木斯大学化学与药学院

出　　处：《黑龙江医药科学》2000年第1期20-20,共1页Heilongjiang Medicine and Pharmacy

摘　　要：本文采用pH滴定法测定甲硝唑原料药的含量．先向甲硝吐中加入过量定量的盐酸标准没（005mol／L），再用NaOH标准液（0．1mol／L）回滴至指定pH，以△VNaOH对甲硝吐浓度C制定工作曲线，线性关系在0．8mg／m1-48mg／ml范围内良好．平均回收率为100．7％，RSD为0．37％．通过t检验和F检验（P＜0．05）本法与非水滴定法在准确度与精密度上无显著性差异．Metronidazole was determined quantitatively by pH titration method. First overdose and quantitative 0.05mol/L HCl was added to metronidazole; then, it was titrated by 0. 1mol/L NaoH at the pH that had been designated. The average recovery and the relative standard deviation were 100.7% and 0.37%, respectively.The result was satisfactory.

关 键 词：PH滴定法 甲硝唑 含量测定 抗原虫药 

分 类 号：R978.61[医药卫生—药品] R927.2[医药卫生—药学]