右美托咪定对病态肥胖的阻塞性睡眠呼吸暂停综合征患者的血气分析  

Dexmedetomidine on the hemodynamics and blood gas analysis in morbidly obese patients with obstructive sleep apnea

作　　者：葛云芬[1] 胡双飞[1] 

机构地区：[1]浙江省人民医院麻醉科,杭州310014

出　　处：《中国临床药理学杂志》2012年第12期944-946,共3页The Chinese Journal of Clinical Pharmacology

基　　金：浙江省医学会临床科研基金资助项目(2010ZYC-A05)

摘　　要：目的评价右美托咪定对病态肥胖的阻塞性睡眠呼吸暂停综合征患者血气分析的影响。方法 40例ASAⅢ级欲行悬雍垂腭咽成形术的病态肥胖的阻塞性睡眠呼吸暂停综合征患者,随机分成右美托咪定组和安慰剂组,右美托咪定组给予负荷剂量1μg·kg-1(20 min)的右美托咪定,安慰剂组则给予容量和外形相似的生理盐水。观察用药后患者的血流动力学及用药前后血气分析的变化。结果右美托咪定组20 min后的心率(HR)、平均血压(BP)、血氧分压(PaO2)与安慰剂组相比显著降低;二氧化碳分压(PaCO2)及pH值与安慰剂组相比差异无统计学意义。结论短时间内大剂量的右美托咪定应用于病态肥胖的阻塞性睡眠呼吸暂停综合征患者也可以产生呼吸抑制。Objective To assess the effect of dexmedetomidine on the hemodynamics and blood gas analysis in morbidly obese patients with obstructive sleep apnea. Methods Forty patients scheduled for uvulo- palatopharyngoplasty were randomized assigned into receive dexmedetoml- dine group or placebo group, respectively. In dexmedtomidine group pa- tients received a loading dose of dexmedetomidine 1 μg . kg-1during 20 minutes, In placebo group patients received a volume matched 0.9% sa- line. Heart rate （HR） ,blood pressure （BP） and blood gas analysis were monitored. Results HR, mean arterial blood pressure and arterial PaO2 presented a statistically significant reduction in the dexmedetomidine group after 20 minutes as compared to the placebo group. Blood PaCO2 and pH were similar for both groups. Conclusion Dexmedetomidine produced respiratory depression in morbidly obese patients with obstruc- tive sleep apnea.

关 键 词：右美托咪定 病态肥胖 阻塞性睡眠呼吸暂停综合征 血气分析 

分 类 号：R971.3[医药卫生—药品] R563.8[医药卫生—药学]