Derivation of Germline Competent Rat Embryonic Stem Cells from DA Rats  

作　　者：Tianda Li Xiao-Yang Zhao Fei Teng Xin Li Minggui Jiang Wei Li Xuepeng Wang Jialiang Wang Lei Liu Zhonghua Liu Liu Wang Qi Zhou 

机构地区：[1]College of Life Sciences, Northeast Agricultural University of China, Harbin 150030, China [2]State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]Graduate School of Chinese Academy of Sciences, Beijing 100039, China [4]College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, China

出　　处：《Journal of Genetics and Genomics》2012年第11期603-606,共4页遗传学报（英文版）

基　　金：supported by the grants from the China National Basic Research Program(No.2012CB966501) to X.Z;the National High Technology R&D Program of China (No.2011AA020108) to Q.Z.;the "Strategic Priority Research Program" of the Chinese Academy of Sciences(No. XDA01030101)

摘　　要：The laboratory rat was one of the earliest mammalian species for scientific research and used as animal disease models in physiology, toxicology, behavior, immunology, and tumor-biology for over 150 years （Jacob, 1999）. However, rat lags far behind mouse in generating human disease models and functional genomic studies because of the lack of authentic rat embryonic stem （ES） cells （Voigt and Serikawa, 2009）,The laboratory rat was one of the earliest mammalian species for scientific research and used as animal disease models in physiology, toxicology, behavior, immunology, and tumor-biology for over 150 years （Jacob, 1999）. However, rat lags far behind mouse in generating human disease models and functional genomic studies because of the lack of authentic rat embryonic stem （ES） cells （Voigt and Serikawa, 2009）,

分 类 号：Q813[生物学—生物工程] Q959.837