子宫腺肌症患者在位与异位内膜组织中HLA-G的表达及意义  

Expressions and significances of HLA-G in eutopic and ectopic endometrium of adenomyosis

作　　者：谭金凤[1] 王宁宁[1] 吴艳欣[1] 谢洪哲[1] 廖悦华[3] 刘泳冬 钟苗[1] 梁莉莉[1] 

机构地区：[1]中山大学附属第一医院妇产科,广州市510080 [2]病理科 [3]广东省江门市中心医院病理科,529030

出　　处：《实用医学杂志》2012年第24期4073-4076,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金(编号:81170550,30672222);广东省自然科学基金(编号:8151008901000124);广东省科技计划项目(编号:2010B050700009,2007B080701011);广东省科技计划项目(编号:2007B080701011036);广州市科技计划项目(编号:2010Y-C011);广东省医学科学技术研究基金(编号:A2009672)

摘　　要：目的:探讨子宫腺肌症(AM)患者在位与异位内膜中人类白细胞抗原-G(HLA-G)的表达情况及意义。方法:选择36例AM患者的在位与异位内膜组织为研究对象,以35例非AM患者的子宫内膜组织为对照。采用免疫组化二步法检测各组内膜HLA-G的表达情况。结果:在位与异位内膜组织HLA-G的阳性表达率均较对照组高(P=0.00060.05,0.0059),在位与异位内膜间HLA-G的阳性表达率以及阳性表达程度差异均无显著性(P=0.4577,P<0.05),且HLA-G的表达与月经周期无明显相关性。结论:AM患者在位与异位内膜中均可见HLA-G的异常表达,HLA-G可能在AM的发病中起重要作用。Objective To investigate the expressions of human leukocyte antigen-G （HLA-G） in eutopic and ectopic endometrium of adenomyosis. Methods The eutopic and ectopic endometrium from 36 patients with adenomyosis were collected as study subjects, and the endometrium from 35 patients with non-endometriosis disease were collected as controls. The expressions of HLA-G in endometrium were measured by immunohistochemical two- step method. Results The positive expression rates of HLA-G in eutopic and ectopic endometrium were significantly higher than that in controls （P 〈 0.05）, and there were no significant differences of the positive expression rate and the degree of positive expression between eutopic and ectopic endometrium. There was no significant correlation between the expression of HLA-G and menstrual cycle. Conclusion HLA-G was abnormally expressed in eutopic and ectopic endometrium of adenomyosis, HLA-G may be involved ,in the pathogenesis of endometriosis.

关 键 词：子宫内膜异位症 子宫腺肌症 人类白细胞抗原 子宫内膜 

分 类 号：R711.71[医药卫生—妇产科学]