可溶性细胞间黏附分子-1在HBV感染不同免疫状态患者血清中变化  

Relationship between the different immune status of HBV infection and the expression of sICAM-1

作　　者：张艳平[1] 

机构地区：[1]湖南常德职业技术学院医学系,湖南常德415000

出　　处：《现代预防医学》2012年第24期6471-6472,6476,共3页Modern Preventive Medicine

摘　　要：目的观察乙型病毒性肝炎(HBV)感染不同免疫状态及HBV感染相关原发性肝癌(PHC)患者可溶性细胞间黏附分子-1(sICAM-1)的变化及其意义。方法利用ELISA法对60例HBV感染耐受、60例免疫清除、60例免疫不全(其中免疫不全A组30例,B组30例)及60例HBV感染性PHC患者进行血清sICAM-1检测,另选30例非HBV感染健康体检者作为正常对照组。结果 HBV感染不同免疫状态者中免疫清除、免疫不全A、免疫不全B及HBV感染相关PHC患者sICAM-1较正常对照组升高,差异有统计学意义(P﹤0.05);免疫耐受、免疫不全A组与正常对照组相比差异无统计学意义(P﹥0.05)。结论检测血清sICAM-1变化对判断HBV感染不同免疫状态病情变化具有一定的临床意义。OBJECTIVE To study the expression and significances of the serum levels of soluble intercellular adhesion molecule-1 （slCAM-1） in patients with different immune status of hepatitis B virus （HBV） infection and Primary Hepatocel- lular Carcinoma （PHC）. METHODS The patients of HBV infection were grouped into five teams, 60 cases were immune toler- ance to HBV, 60 cases were immune clearance （30 cases with immunodeficiency in group A and another 30 cases with immun- odeficiency in group B） with 30 patients in either groups, and 60 patients were diagnosed as PHC clinically. Serum samples were collected from these patients, and 30 healthy volunteers were taken as control for the study. The serum levels of sICAM-1 were measured by enzyme-linked immunosorbent assay （ELISA）. RESULTS Serum levels of sICAM-1 in patients with immune clearance immunodeficiency （B） and PHC were significantly increased, and there was significant difference when compared with normal control （P 〈 0.05）. Serum levels of slCAM-1 in patients with immune tolerance and immunode-ficiency （A） were not significantly different when compared with those in the normal control （P 〉 0.05）. CONCLUSION Serum levels of slCAM-1 may reflect the disease progressed in patients with different immune status of HBV and have certainly valuable for clinical signifi- cance.

关 键 词：HBV感染 不同免疫状态 SICAM-1 

分 类 号：R392.7[医药卫生—免疫学]