深吸气量检测在慢性阻塞性肺疾病诊断中的临床意义  

Clinical significance of inspiratory capacity in diagnosis of chronic obstructive pulmonary disease

作　　者：陈培[1] 官和立[1] 杨恂[1] 张怡[1] 

机构地区：[1]成都大学附属医院呼吸内科,四川成都610081

出　　处：《现代预防医学》2012年第24期6492-6494,共3页Modern Preventive Medicine

基　　金：四川省卫生厅科研项目(100075)

摘　　要：目的探讨吸入支气管扩张剂后深吸气量(inspiratory capacity,IC)变化率在诊断慢性阻塞性肺疾病(chronicobstructive pulmonary disease,COPD)中的临床意义。方法对COPD患者组130例,非COPD患者组79例,进行常规肺功能检查,检测到吸入支气管扩张剂后IC前后变化率及1秒率指标。结果以1秒率作为"金标准"计算吸入支气管扩张剂后IC变化率的敏感度、特异度、阳性似然比、阴性似然比、诊断比值比,Pearson Chi-Squares检验,Youden指数,绘制ROC曲线。其最佳截点8.44%,敏感度为86.9%,特异度为83.5%。结论吸入支气管扩张剂后IC变化率在COPD的诊断、鉴别诊断、初筛具有临床意义。OBJECTIVE To explore the clinical significance of inspiratory capacity changes of chronic obstructive pulmonary disease. METHODS 130 patients with COPD and 79 cases with non-COPD patients were studied, and all patients had conven- tional pulmonary function tests. RESULTS The sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, di- agnostic odds ratio, Pearson Chi-Squares test, Youden index of IC changes of the 2 groups were calculated by FEVI/FVC as the ＂gold standard＂, and the ROC curve was drawn, of which the best cut-off point was 8.44%, sensitivity was 86.9% and specificity was 83.5%. CONCLUSION IC changse in the inhaled bronchodilators have clinical significance in COPD, and it can be used for diagnosis, differential diagnosis, primary screening of COPD.

关 键 词：慢性阻塞性肺疾病 诊断性试验 深吸气量 

分 类 号：R563[医药卫生—呼吸系统]