地氟醚复合麻醉对冠心病高危因素病人心率变异性的影响  

Effects of desflurane on heart rate variability in patients at risk for coronary artery disease

作　　者：陈晓光[1] 王俊科[1] 张晓光[1] 马虹[1] 盛卓人[1] 

机构地区：[1]中国医科大学附属第一临床学院麻醉科,沈阳市110001

出　　处：《中华麻醉学杂志》2000年第3期149-151,共3页Chinese Journal of Anesthesiology

摘　　要：目的　研究地氟醚复合麻醉对冠心病高危因素病人自主神经系统功能的影响。方法　30例择期腹部手术病人 ,术前确诊为冠心病高危人群。用动态心电图仪记录诱导前、呼气末地氟醚浓度在 0 5、1 0、1 5、2 0MAC时的心率变异性。结果　在低浓度地氟醚麻醉下低频功率明显高于基础值 (P <0 0 5 ) ;随着吸入浓度增加 ,低频、高频功率均下降 (P <0 0 5 ) ;LF/HF比值与基础值相比无明显变化 (P >0 0 5 )。结论　地氟醚复合麻醉使自主神经活性呈进行性抑制 ,在辅用氧化亚氮。Objective To investigate the effect of desflurane anesthesia on the autonomic nervous system in patients at high risk for coronary artery disease.Methods Thirty patients at high risk for coronary artery disease scheduled for elective abdominal operation were selected. Heart rate variability (HRV) was assessed at preoperation, inhalation of 05,10,15 and 20 MAC of desflurane with Holter electrocardiography Results Low-frequency component increased markedly inhaling low concentration of desflurane. With the increase of the concentration of desflurane, both the high-frequency and low-frequency components decreased significantly (P<0 05); the ratio of low-frequency component to high-frequency component did not change significantly during desflurane anesthesia comparing with the preoperative value (P>0 05).Conclusions Desflurane balanced anesthesia dose not increase the activity of sympathetic nervous system.

关 键 词：地氟醚 复合麻醉 心率变异性 冠心病 

分 类 号：R614.27[医药卫生—麻醉学]