异丙酚对老年及成年大鼠血脑屏障通透性的影响  

Influence of blood brain barrier permeability by propofol in aged and adult rats

作　　者：苏小军[1] 宋运琴[2] 陈知进[2] 张宏[2] 

机构地区：[1]中国人民解放军第三○四医院麻醉科,北京市100037 [2]中国人民解放军总医院麻醉科

出　　处：《中华麻醉学杂志》2000年第3期169-171,共3页Chinese Journal of Anesthesiology

摘　　要：目的　探讨异丙酚对老年及成年大鼠血脑屏障通透性的影响。方法　用依文氏蓝染色及光镜、电镜方法 ,观察老年及成年大鼠静脉恒速分别输入高浓度和低浓度异丙酚后 ,其血脑屏障通透性和脑形态结构的变化。结果　 (1)输入高浓底和低浓度异丙酚 1h对老年及成年大鼠血脑屏障通透性无影响 ;(2 )HE染色光镜观察各组脑结构均正常 ;(3)电镜下见各组的镧离子均在血管腔内 ,脑组织结构正常。结论　能引起脑电图爆发抑制且循环改变不大剂量的异丙酚 。Objective To evaluate the influence of propofol on the permeability of the blood brain barrier(BBB) in adult and aged rats.Methods Aged or adult rats were given two doses propofol in 1 hour,respectively.BBB permeability was examined by optical microscopy,electromicroscopy and Evans blue(EB) staining.Results (1)Brain EB staining was not seen in aged or adult groups that at either dose of propofol.(2)In all groups of aged and adult rats,the structure of the blood vessels was normal and lanthanum was not seen outside the blood vessels.(3)There were no significant changes in the central nervous system under microscope or electromicroscope in any groups.Conclusions Propofol at the two doses has no significant effect on BBB permeability or on the central nervous system morphology in aged and adult rats.

关 键 词：血脑屏障 异丙酚 通透性 老年人 麻醉药 

分 类 号：R971.2[医药卫生—药品] R614[医药卫生—药学]