sCD_(40)L、IL-10在2型糖尿病患者下肢血管病变中的变化  

Change of sCD_(40)L and IL-10 in Patients with Type 2 Diabetes with the Legs Vascular Complications

作　　者：白琳[1] 邓洋[2] 邬月琴[1] 

机构地区：[1]包头医学院第一附属医院内分泌科,内蒙古包头014010 [2]包头医学院,内蒙古包头014010

出　　处：《中国医药指南》2012年第33期399-400,共2页Guide of China Medicine

基　　金：包头医药卫生基金;项目名称:sCD40L;IL-10与2型糖尿病患者血管病变的相关性研究;编号201052001-1

摘　　要：目的研究sCD40L、IL-10在糖尿病下肢血管病变发生发展中的作用及其相关性。方法 2型糖尿病患者无下肢血管病变组54例,糖尿病下肢血管病变组36例,采用ELISA法测定患者血清sCD40L、IL-10,并同时测定血脂、糖化血红蛋白。结果 sCD40L糖尿病下肢血管病变组高于无糖尿病下肢血管病变组(P<0.05);IL-10糖尿病下肢血管病变组低于无糖尿病下肢血管病变组。sCD40L与IL-10呈负相关。各组GHbA1c、TC、LDL、HDL均没有统计学差异,TG有下肢血管病变组高于无下肢血管病变组。结论随着糖尿病病情的进展sCD40L水平逐渐升高,IL-10逐渐减低。Objective To study relations between serum sCD40L,IL-10 and occurrence and development of diabetes with the legs vascular complications.Method The research included 54 cases for the groups of diabetes non-the legs vascular complications,36 cases for the groups of diabetes with the legs vascular complications,ELISA method was used to determine serum sCD40L and IL-10 of the patients,while determine blood lipid and glycated hemoglobin.Results sCD40L lever of diabetes with the legs vascular complications group was significantly higher than diabetes non-the legs vascular complications,IL-10 level of diabetes with the legs vascular complications group was significantly lower than diabetes non-the legs vascular complications group.sCD40L was negatively correlated with IL-10.TG of diabetes with the legs vascular complications group was significantly higher than that of diabetes non the legs vascular complications,and there were no statistical difference in the TC,HDL,LDL,HbA1c of the diabetes with the legs vascular complications group compared with diabetes non-the legs vascular complications group.Conclusion Along with the progress of diabetic,sCD40L level was rising,IL-10 gradually declined.

关 键 词：糖尿病下肢血管病变 SCD40L IL-10 

分 类 号：R587.2[医药卫生—内分泌]