重型肝炎并发肝性脑病的影响因素研究  

Influential Factors for Severe Hepatitis with Hepatic Encephalopathy

作　　者：吕日英[1] 吴继周[2] 李仕雄[1] 

机构地区：[1]广西医科大学第八附属医院感染科,广西贵港市537100 [2]广西医科大学第一附属医院感染科,广西南宁市530021

出　　处：《中华全科医学》2012年第12期1847-1849,共3页Chinese Journal of General Practice

摘　　要：目的分析重型肝炎并发肝性脑病(HE)的发病率,研究重型肝炎伴HE患者与单纯重症肝炎患者的临床资料和血液生化指标,探讨重型肝炎并发HE的影响因素。方法回顾性分析广西医科大学第八附属医院2008年6月-2011年6月因重型肝炎住院的145例患者。根据患者住院期间是否发生HE,将研究对象分成重型肝炎伴HE(HE组,52例)和单纯重型肝炎组(非HE组,93例)。比较两组患者的肝肾综合征等其他并发症患病率和血液生化指标,并运用非条件Logistic回归模型进行多因素分析。结果重型肝炎并发HE的患病率为35.9%(52/145)。多因素Logistic回归结果显示,进入回归方程的主要因素为:国际标准化比值(INR)(OR=1.57,95%CI:1.04～2.44)、血氨(OR=1.03,95%CI:1.02～1.04)。结论重型肝炎并发HE的患病率较高,国际标准化比值和血氨是影响重型肝炎并发HE的主要危险因素。Objective To investigate the prevalence rate of hepatic encephalopathy （HE） among severe hepatitis patients, discuss the related influential factors. Methods Total 145 patients with severe hepatitis were enrolled in this study. 52 patients with HE were assigned into HE group and 93 patients without HE into control group. The laboratory indicator, prevalence rate of hepatorenal syndrome and other complications were compared between the two groups. Multivariate analysis was explored by un- conditional logistic regression. Results The prevalence rate of HE among severe hepatitis patients was 35.9% （52/145）. Logis- tic regression showed that the international normalized ratio（INR） （ OR = 1.57,95% CI： 1.04 - 2.44）, ammonia（ OR = 1.03, 95% CI：I. 02 -1.04） were the risk factors of HE in patients with severe hepatitis. Conclusion The prevalence rate of HE a- mong severe hepatitis patients was high. The international normalized ratio（INR） and blood ammonia were the risk factors of HE in patients with severe hepatitis.

关 键 词：重型肝炎 肝性脑病 影响因素 LOGISTIC回归分析 

分 类 号：R512.6[医药卫生—内科学] R742[医药卫生—临床医学]