右美托咪啶预防全麻心血管反应在妇科手术中的临床观察  

The Effects of Dexmedetomidine Hydrochloride on Cardiovascular Responses in Anesthesia Recovery Period

作　　者：程斌 欧英余 黄婧 

机构地区：[1]四川省成都市妇女儿童中心医院麻醉科,610091

出　　处：《中华全科医学》2012年第12期1884-1884,1985,共2页Chinese Journal of General Practice

摘　　要：目的观察盐酸右美托咪啶对全麻患者苏醒期心血管反应的影响,借此探讨其相关的临床应用价值。方法收集医院2012年5月-2012年7月需要全身麻醉下择期行腹部手术的女性患者60例,将患者随机分为对照组(A)和盐酸右美托咪啶治疗组(B),每组30例。检测患者麻醉自主呼吸恢复时、拔管时和拔管后10 min的心率(HR)、平均动脉压(MAP)、心率收缩压乘积(RPP),记录患者苏醒时间(呼之睁眼的时间)、拔管时间、呼吸恢复时间。结果两组患者HR、MAP、RPP在麻醉前和拔管前差异都无统计学意义(P>0.05),但拔管后以及拔管10 min后上述指标A组较拔管前有显著的升高(P<0.05),而B组则无显著性变化(P>0.05)。两组患者在麻醉后苏醒、拔管和呼吸恢复时间之间差异无统计学意义(P>0.05)。结论盐酸右美托咪啶可以全麻苏醒期的血流动力学稳定,对麻醉恢复期没有影响,作为全麻的辅助用药值得临床推广应用。Objective To investigate the effects of dexmedetomidine hydrochloride on cardiovascular responses in anesthesia recovery period. Methods A total of 60 patients underwent selective abdominal operation under general anesthesia were enrolled in this study. All cases were divided into two groups ： control group （ A, n = 30 ） and dexmedetomidine hydrochloride treatment group （B, n = 30）. Heart rate（HR）, mean arterial blood pressure （MAP）, and the rate-pressure product （RPP） were detected at recovery of drowsiness and after-extubation treated 0, and 10 min, respectively. The recovery period with drowsiness, tracheal extu- bation,and respiratory depression were recorded. Results HR, MAP, and RPP were not significandy different between the two groups at pre- extubation（ P 〉 O. 05 ）. However HR, MAP, and RPP were changed in A group in anesthesia recovery period（ P 〈 O. 05 ）. After dexmedetomidine hydroehloride treatment, the HR, MAP, and RPP in B group were not changed （ P 〉 0.05 ）. There were no significant differences in the recovery time of drowsiness, extubation time and respiratory depression between the two groups （ P 〉 0.05 ）. Conclusion Dexmedetomidine hydrochloride can effectively reduce cardiovascular responses in anesthesia recovery period, and while did not prolonging the recovery time from anesthesia.

关 键 词：盐酸右美托咪啶 全麻苏醒期 心血管反应 

分 类 号：R614.2[医药卫生—麻醉学]