桑叶多糖对糖尿病大鼠Resistin蛋白表达的影响  

Effect of Mulberry Leaves Polysaccharides on Protein Expression of Resistin in Type 2 Diabetes Mellitus Rats

作　　者：任岩海[1] 刘洪凤[2] 宋铁军[3] 韩智学[2] 

机构地区：[1]牡丹江医学院红旗医院,黑龙江牡丹江157011 [2]牡丹江医学院,黑龙江牡丹江157011 [3]牡丹江医学院第二附属医院,黑龙江牡丹江157011

出　　处：《中医药信息》2012年第6期22-23,共2页Information on Traditional Chinese Medicine

基　　金：黑龙江省牡丹江市科学技术计划研究项目(Z2011s002)

摘　　要：目的:探讨桑叶多糖(Mulberry leaves polysaccharides,MLP)对2型糖尿(T2DM)病大鼠脂肪组织抵抗素(Resistin)蛋白表达的影响。方法:将Wistar大鼠随机分为空白对照组、模型组、MLP高、中、低剂量治疗组。用药12W后,采用SDS-PAGE检测Resistin蛋白质表达水平。结果:MLP高、中剂量治疗组Resistin蛋白表达低于模型组水平(P<0.01)。结论:MLP可通过下调2-DM大鼠Resistin蛋白表达,从而实现其降低IR的作用。Objective：To investigate the effect of Mulberry leaves polysaccharides on rats with type 2 diabetes and the protein expression of Resistin.Methods：Wistar rats were randomly divided into control group,model group and high,middle,low doses of MLP groups.Expression of Resistin protein was detected by SDS-PAGE at the end of 12 weeks.Results：The protein expression of Resistin decreased in the middle and high doses of MLP groups（P0.01）.Conclusion：MLP can decrease insulin resistance by decreasing protein expression of Resistin in type 2 diabetes rats.

关 键 词：桑叶多糖 T2DM 胰岛素抵抗 抵抗素 

分 类 号：R285.5[医药卫生—中药学]