Asymmetric Aldol Reaction Catalyzed by Modularly Designed Organocatalysts  

作　　者：Sinha, Debarshi Mandal, Tanmay Gogoi, Sanjib Goldman, Joshua J. 赵从贵 

机构地区：[1]Department of Chemistry, University of Texas at San Antonio One UTSA Circle, San Antonio, Texas 78249-0698, USA

出　　处：《Chinese Journal of Chemistry》2012年第11期2624-2630,共7页中国化学（英文版）

摘　　要：The self-assembly of the precatalyst modules, which are amino acids and cinchona alkaloid derivatives, leads to the direct formation of the desired organocatalysts without any synthesis. These modularly designed organocatalysts （MDOs） may be used for catalyzed asymmetric aldol reaction the corresponding aldol products may be obtained in mediocre diastereoselectivities （up to 79 ： 21 dr）. Depending on structure of the aldehyde substrates, to excellent ee values （up to 92% ee） with moderateThe self-assembly of the precatalyst modules, which are amino acids and cinchona alkaloid derivatives, leads to the direct formation of the desired organocatalysts without any synthesis. These modularly designed organocatalysts （MDOs） may be used for catalyzed asymmetric aldol reaction the corresponding aldol products may be obtained in mediocre diastereoselectivities （up to 79 ： 21 dr）. Depending on structure of the aldehyde substrates, to excellent ee values （up to 92% ee） with moderate

关 键 词：modularly designed organocatalysts aldol reaction asymmetric catalysis amino acid cinchona alka-loid thiourea 

分 类 号：TQ324.9[化学工程—合成树脂塑料工业] TQ655