Formation of Chiral a-Monofluorinated-.8-amino Esters through Organocatalytic Asymmetric Reduction of a-Fluoro-j3-enamino Esters by Trichlorosilane  

作　　者：张鹏 王超 周莉 孙健 

机构地区：[1]Natural Products Research Center,Chengdu Institute of Biology,Chinese Academy of Sciences,Chengdu,Sichuan 610041,China

出　　处：《Chinese Journal of Chemistry》2012年第11期2636-2640,共5页中国化学（英文版）

基　　金：Acknowledgement We are grateful for financial supports from the Na- tional Natural Science Foundation of China （Project Nos. 20972151, 21272227 and 91013006）.

摘　　要：A concise method was developed to prepare chiral a-monofluorinated-β-amino esters through N-sulfinyl urea catalyzed asymmetric hydrosilylation of a-fluoro-β-enamino esters, which affords high yields, good to high di- astereoselectivities （up to〉99/1）, and moderate to good enantioselectivities （up to 83% ee）.A concise method was developed to prepare chiral a-monofluorinated-β-amino esters through N-sulfinyl urea catalyzed asymmetric hydrosilylation of a-fluoro-β-enamino esters, which affords high yields, good to high di- astereoselectivities （up to〉99/1）, and moderate to good enantioselectivities （up to 83% ee）.

关 键 词：asymmetric reduction sulfinyl urea a-fluorinated-β-amino ester STEREOSELECTIVITY 

分 类 号：O621.34[理学—有机化学] O623.12[理学—化学]