Stereoselective Synthesis of Optically Active Hydrobenzoins via Asymmetric Hydrogenation of Benzils with Ru（OTf）（TsDPEN）（η6-cymene） as the Pre-catalyst  

作　　者：黄晓飞 李乃凯 耿志聪 潘锋锋 王兴旺 

机构地区：[1]Key Laboratory of Organic Synthesis of Jiangsu Province,College of Chemistry and Chemical Engineering,Suzhou University,Suzhou,Jiangsu 215123,China

出　　处：《Chinese Journal of Chemistry》2012年第11期2657-2663,共7页中国化学（英文版）

基　　金：Acknowledgement We are grateful for financial support from the Na- tional Natural Science Foundation of China （NSFC） （21072145）, the Foundation for the Authors of National Excellent Doctoral Dissertations of PR China （200931）, and the Natural Science Foundation of Jiangsu Province of China （BK2009115）. This project was also funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions （PAPD）.

摘　　要：Optically active hydrobenzoins are very important building blocks for further derivation of biologically active complexes, natural products, and pharmaceutical compounds. In this paper, A practical approach has been devel- oped for asymmetric hydrogenation of benzils with Ru（OTf）（TsDPEN）（rl6-cymene） as a pre-catalyst in methanol. Therefore, a series of chiral hydrobenzoins was synthesized in good yields with good to moderate diastereoselectiv- ities and good to excellent enantioselectivities.Optically active hydrobenzoins are very important building blocks for further derivation of biologically active complexes, natural products, and pharmaceutical compounds. In this paper, A practical approach has been devel- oped for asymmetric hydrogenation of benzils with Ru（OTf）（TsDPEN）（rl6-cymene） as a pre-catalyst in methanol. Therefore, a series of chiral hydrobenzoins was synthesized in good yields with good to moderate diastereoselectiv- ities and good to excellent enantioselectivities.

关 键 词：asymmetric catalysis BENZIL RUTHENIUM hydrogenation hydrobenzoin 

分 类 号：TQ453.4[化学工程—农药化工] TQ426.94