BDNF在甲基苯丙胺依赖机制中作用研究进展  

New Development in Role of BDNF in the Mechanism of Methamphetamine Dependence

作　　者：刘巨鹏 洪仕君[1] 李利华[2] 

机构地区：[1]昆明医科大学法医学院,云南昆明650500 [2]昆明医科大学科学技术处,云南昆明650500

出　　处：《昆明医科大学学报》2012年第10期159-162,共4页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81060253)

摘　　要：脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)对于神经元的生长、分化、存活、可塑性及损伤后的修复具有重要作用,能有效阻止甲基苯丙胺诱导神经元死亡.阐述了甲基苯丙胺毒性作用机制,BDNF生理作用及BDNF在甲基苯丙胺依赖机制中作用.BDNF在甲基苯丙胺依赖过程中可能起到重要的作用,对BDNF作用机制的研究将为甲基苯丙胺依赖机制和戒毒治疗提供理论依据.Brain-derived neurotrophic factor plays an important role in neuron growth,differentiation,survival,plasticity and damage repair,and it can effectively prevent the methamphetamine-induced neuronal death.The article describes the mechanism of the toxic effects of methamphetamine,BDNF physiological role,and the role of BDNF in methamphetamine-dependent mechanism.BDNF may play an important role in methamphetamine dependence.The clarification of role of BDNF in the methamphetamine-dependent mechanism may provide a theoretical basis for detoxification treatment.

关 键 词：脑源性神经营养因子 甲基苯丙胺 依赖机制 

分 类 号：R961[医药卫生—药理学]