2型糖尿病合并贫血的相关分析  

Determinants of anemia in patients with type 2 diabetes mellitus

作　　者：梁焯辉[1] 刘倩雯[1] 赵凡[1] 

机构地区：[1]广东省江门市人民医院内分泌科,广东江门529000

出　　处：《中国医药科学》2012年第21期112-113,134,共3页China Medicine And Pharmacy

摘　　要：目的评估2型糖尿病患者贫血的影响因素。方法本研究为病例对照研究,108例患者被分为两组:贫血组54例糖尿病合并贫血患者,非贫血组为54例糖尿病不伴贫血患者,从临床和实验室收集资料。结果贫血患者的年龄、糖尿病病程、肌酐、C反应蛋白、尿蛋白明显高于非贫血患者,白蛋白水平、肌酐清除率明显低于贫血患者;血红蛋白与白蛋白、肌酐清除率正相关;与糖尿病病程、肌酐、CRP、尿蛋白、年龄负相关;多元回归分析显示:白蛋白、肌酐清除率、尿蛋白、糖尿病病程是血红蛋白的浓度的影响因子;Logistic回归分析显示:白蛋白、肌酐清除率、尿蛋白、糖尿病病程也是糖尿病患者贫血影响因素。结论贫血是多因素的结果,白蛋白、肌酐清除率、尿蛋白、糖尿病病程、微炎症反应等因素不同程度地影响血红蛋白浓度。Objective To evaluate the risk factors of anemia in a diabetic population and to explore the relationship between hemoglobin and clinical parameters. Methods This was a case-control study on risk factors of patients with anemia in type 2 diabetes mellitus. 108 patients were classified into two groups （each group was 54 cases）, clinical and laboratory data were collected. Results The age、duration of T2DM、creatinine、C-reactive protein、albuminuria of patients who had anemia were significantly higher than in patients without anemia. Levels of Albumin、estimated glomerular filtration rate were lower than the group without anemia. A positive correlation was found between hemoglobin with albumin、eGFR, and a negative correlation was found between hemoglobin levels with duration of T2DM, creatinine, C-reactive protein, albuminuria and age. Multiple regression analysis identified Albumin, eGFR, albuminuria and duration of T2DM as independent determinants of hemoglobin concentration. Logistic regression analysis showed that albumin, eGFR, albuminuria and duration of T2DM were also predictor for anemia. Conclusion Anemia is a multifactorial result, in evaluating hemoglobin levels in T2DM patients, we must keep in mind that albuminuria, albumin, duration of DM, eGFR ,microinflammation can affect the hemoglobin levels of varying degrees.

关 键 词：贫血 糖尿病 血红蛋白 白蛋白 肌酐 

分 类 号：R587.1[医药卫生—内分泌]