3-磷酸甘油醛脱氢酶测定在糖尿病肾病诊断中的临床意义  

Diagnositic value of glyceraldehyde-3-phosphate dehydrogenase determination in diabetes nephropathy

作　　者：张一兵[1] 时娟[1] 张淑芹[1] 

机构地区：[1]辽宁医学院附属第三医院临床检验中心,辽宁锦州121000

出　　处：《中国医药科学》2012年第22期116-117,130,共3页China Medicine And Pharmacy

摘　　要：目的通过测定血中3-磷酸甘油醛脱氢酶的活性,探讨GAPD在糖尿病肾病早期诊断中的意义。方法测定190例健康者和80例2型糖尿病患者的血GAPD,尿微量白蛋白和β2-微球蛋白,对结果进行统计分析。结果疾病组中GAPD活性水平均高于正常对照组,差异有统计学意义(P<0.05)。疾病组中的微量白蛋白尿组、大量白蛋白尿组中的微量白蛋白和β2-微球蛋白高于正常对照组,差异有统计学意义(P<0.05)。但是正常白蛋白尿组中的微量白蛋白和β2-微球蛋白与对照组相比差异无统计学意(P>0.05)。结论 GAPD在正常白蛋白尿期活性已经发生变化,比微量白蛋白和β2-微球蛋白活性变化更早,能够提早预测糖尿病肾脏疾病的发生,有利于临床做出诊断,改善患者的预后。Objective To explore the significance of GAPD in diabetic nephropathy through determining the activity of blood GAPD.Methods To analyze the determined results of 190 healthy and 80 patients of type 2 diabetes patients,the activity of GAPD,microalbuminuria and β2-micro-globulin.Results Activity of GAPD in three disease group were higher than the normal group（P0.05）.mALB and β2-M in two disease group of the abnormal microalbuminuria group were higher than the control group（P0.05）,but compared with the control group mALB and β2-M in normal albuminuria group had no significant difference（P0.05）.GAPD in disease group had no difference（P0.05）.mALB and β2-M meaningful were differences between the three groups（P0.05）.Conclusion Activity of GAPD has been changed in normal proteinuria and earlier than mALB and β2-M.It can be forecast early diabetic kidney disease,easy to make a diagnosis for clinic and improve the prognosis of patients.

关 键 词：3-磷酸甘油醛脱氢酶 2型糖尿病 微量白蛋白 Β2-微球蛋白 

分 类 号：R587.1[医药卫生—内分泌]