开放血管平滑肌细胞Kir6.1/SUR2B降低去窦弓神经大鼠血压波动性  

Opening of Kir6.1/SUR2B on vascular smooth cells decreases blood pressure variability in sinoaortic denervated rats

作　　者：张伟[1] 赵心彬[2] 杨宏[2] 倪敏[2] 

机构地区：[1]中国人民解放军总后勤部第二门诊部药房,北京100071 [2]第二军医大学长征医院药剂科,上海200003

出　　处：《第二军医大学学报》2012年第12期1315-1318,共4页Academic Journal of Second Military Medical University

摘　　要：目的探讨心血管系统不同分子组成的ATP敏感钾通道(KATP)在降低去窦弓神经(SAD)大鼠血压波动性(BPV)中的作用。方法建立SAD大鼠模型,利用计算机化清醒自由活动大鼠血流动力学监测技术,观察非选择性KATP开放剂吡那地尔、Kir6.1/Sur2B和Kir6.1/Sur1选择性开放剂二氮嗪对SAD大鼠BPV的影响;并观察用Kir6.1/Sur1选择性阻断剂5-羟基癸酸盐(5-HD)、Kir6.2/Sur2A选择性阻断剂HMR1098阻断KATP后,吡那地尔和二氮嗪对SAD大鼠BPV作用的改变。结果吡那地尔和二氮嗪能够降低SAD大鼠BPV(P<0.01),阻断Kir6.1/Sur1、Kir6.2/Sur2A后不改变吡那地尔和二氮嗪对BPV的降低作用。结论开放血管平滑肌细胞Kir6.1/Sur2B能够降低SAD大鼠的BPV。Objective To determine the role of different molecular compositions of KATp channels in reducing the blood pressure variability （BPV） in conscious, freely-moving sinoaortic denervated （SAD） rats. Methods SAD rat model was established. Computerized analytic system of blood pressure was used to observe the effects of unselective KATp openers （pinacidil） or Kir6.1/Sur2B and Kit6.1/Surl selective opener （diazoxide） on BPV of SAD rats. We also observed the effects of pinacidil and diazoxide on BPV of SAD rats pre-treated with selective Kir6. 1/Surl antagonist 5-hydroxydecanoic acid （5-HD） and selective Kit6.2/Sur2A antagonist （HMR1098）. Results Both pinacidil and diazoxide significantly decreased BPV in SAD rats （P（0. 01） ,and pre-treatment with 5-HD＋ HMR1098 did not change the effect of either pinacidil or diazoxide on BPV of SAD rats. Conclusion Opening Kir6.1/SUR2B of vascular smooth cells can decrease the BPV levels in SAD rats.

关 键 词：去窦弓神经 血压波动性 KATP通道 血管平滑肌 

分 类 号：R331.3[医药卫生—人体生理学]