TNF-α与乙型病毒性肝炎宫内感染的相关性研究  

Correlation of TNF-alpha and intrauterine infection of viralhepatitis B

作　　者：宗禹希[1] 陈萱[1] 吕楠[1] 赵姝妤[1] 

机构地区：[1]哈尔滨医科大学附属第二医院妇产科,黑龙江哈尔滨150086

出　　处：《中国优生与遗传杂志》2012年第12期4-6,共3页Chinese Journal of Birth Health & Heredity

基　　金：黑龙江省教育厅海外学人课题(1153h14);黑龙江省省卫生厅科技攻关课题(2004-126);黑龙江省教育厅科学技术研究项目;项目编号12521347;黑龙江省卫生厅科研课题;项目编号2010-062

摘　　要：亚洲的慢性乙型肝炎携带者约有30%-50%是由于围产期母婴传播造成的,宫内感染是其主要的传播途径,机体感染乙型肝炎病毒后,机体的免疫系统在抗病毒感染中起着重要保护作用,TNF-α主要由单核-巨噬细胞产生的单核因子,具有多种免疫调节作用。它与乙型肝炎、妊娠合并乙型肝炎的相关性引起很多国内外学者的关注。近年来的研究发现,TNF-α与许多妊娠生理或病理过程密切相关。其基因多态性受到越来越多的学者关注,TNF-α启动子区基因多态性通过影响TNF-α的转录调节来影响TNF-α的表达,因此研究TNF-α对了解HBV的发病机制及其作用有着深远的意义,为今后阻断乙型肝炎宫内感染提供新的靶点。In Asia,about 30%-50% of the chronic hepatitis Bcarriers is caused by perinatal mother-infanttransmission,intrauterine infection is the major route of transmission.The body infected with hepatitis B virus,theimmune system in anti-virus infection plays an importantprotective effect.TNF-alpha is produced mainly by monocyte-macrophages monokine,it has multiple immunomodulatoryeffects.Correlation with hepatitis B,pregnancy withhepatitis B,it aroused the concern of many scholars.Recentstudies have found that TNF-alpha is closely related withpregnancy physiological or pathological processes.Genepolymorphisms are more and more scholars are concerned,TNF-alpha promoter region gene polymorphisms influence of TNF-alpha expression by affecting the transcriptionalregulation of TNF-alpha,and therefore to study the incidence of TNF-alpha on the understanding of HBV mechanisms and theirrole has far-reaching significance,a new target for blockinghepatitis B intrauterine infection in the future.

关 键 词：TNF-Α 乙型病毒性肝炎 宫内感染 基因多态性 免疫调节 

分 类 号：R512.62[医药卫生—内科学] R714.2[医药卫生—临床医学]