HIF-1α、VEGF在胎儿生长受限患者胎盘组织中的表达及意义  

Expression of hypoxia-inducible factor-1α,vascular endothelial growth factor and their relationship in placenta of pregnant women with FGR

作　　者：秦江霞[1] 贾金平[1] 岳玉焕[1] 

机构地区：[1]广州市花都区妇幼保健院产科,广州510800

出　　处：《中国优生与遗传杂志》2012年第12期47-48,53,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的通过探讨缺氧诱导因子1α(HIF-1α),靶基因血管内皮生长因子(VEGF)在胎儿生长受限(FGR)患者胎盘组织中的表达,研究FGR的发病机制。方法采用链酶菌抗生物素蛋白-过氧化物酶连接(SP)法检测FGR组和对照组的胎盘组织中的HIF-1α、VEGF的表达,并进行相关性分析。结果①FGR组胎盘组织中HIF-1α阳性表达率明显高于对照组,差异具有统计学意义(P<0.05)。②FGR组胎盘组织中VEGF阳性表达率低于对照组,两者比较,差异有统计学意义。③FGR组患者和对照组胎盘中HIF-1α表达与VEGF变化呈显著负相关(r=-0.622,P<0.05)。结论 HIF-1α在FGR患者胎盘组织中表达升高,通过下调靶基因VEGF,引起VEGF降低,影响胎盘血管重铸,参与胎儿生长受限的发生和发展。Objective：To investigate the expression and correlation of hypoxia-inducible factor-1α（HIF-1α）,vascular endothelial growth factor（VEGF） in placenta of pregnant women with FGR,and discuss their significance in FGR.Methods：The expression to HIF-1α,VEGF were assayed by using SP immunohistochemical method in placentas of the normal pregnant group and FGR group,the relationship of the HIF-1α,VEGF was analyzed.Results： ①The expression of HIF-1α in FGR group obviously increased and was significantly higher than in normal group（P 0.05）.② VEGF expression obviously reduced in FGR group and was significantly lower than in normal group（P 0.05）.③ HIF-1α expression was negatively correlated with the expression of VEGF（r =-0.622,P0.05） in FGR group.Conclusion：Increased HIF-1α expression in FGR placenta indicates HIF-1α might be involved in pathogenesis of FGR,possibly through down-regulating VEGF gene transcription and affecting the placental vascular reconstruction.

关 键 词：胎儿生长受限 缺氧诱导因子-1 血管内皮生长因子 靶基因 

分 类 号：R714.43[医药卫生—妇产科学]