Her-2与ALDH1在乳腺癌中表达与相关性研究  

Studies of correlation between Her-2 and ALDH1 expression in breast cancer

作　　者：玄东春[1] 金文彪[1] 崔海[1] 金永民[1] 崔美女[1] 孙红花[1] 朴龙镇[1] 沈雄虎[1] 张松男[1] 

机构地区：[1]延边大学附属医院,延边133000

出　　处：《现代仪器》2012年第6期26-29,33,共5页Modern Instruments

基　　金：国家自然科学基金(项目编号:81160275);中华医学会临床医学科研专项资金-柯莱逊肿瘤生物治疗研究专项资金(项目编号:2011-14);延边大学科技发展计划项目(2012)第50号

摘　　要：目的:探讨乳腺癌组织中Her-2及ALDH1的表达相关性及其临床意义。方法:选取105例原发性乳腺癌标本。采用免疫组化法检测Her-2、ALDH1蛋白的表达,并结合临床病理特征进行相关性分析和无病生存期分析。结果:(1)Her-2与ALDH1在乳腺癌中的表达率分别为29.52%、66.67%。(2)乳腺癌原发灶中Her-2蛋白的表达与肿瘤大小、ER呈正相关(P≤0.05),与年龄、民族、组织学分期及病理类型、PR均无相关性(P>0.05)。ALDH1蛋白表达与年龄、民族、组织学分期及病理类型、肿瘤大小、淋巴结转移、ER、PR均未发现有相关性(P>0.05)。(3)Her-2与ALDH1在乳腺癌表达中呈正相关(r=0.192,P≤0.05)。(4)Her-2高表达患者2年无病生存率显著低于Her-2阴性患者(P<0.05),ALDH1阳性患者与阴性患者2年无病生存期无明显差异(P>0.05)。(5)COX回归模型分析结果显示Her-2是影响患者预后的独立因素(P=0.008)。Her-2的相对危险度=6.284>1。结论:ALDH1与Her-2在乳腺癌组织中的表达呈正相关。Her-2表达与乳腺癌术后患者预后呈负相关,而ALDH1表达与乳腺癌术后患者的预后无明显相关性。Objective The aim of this study was to analyze the relationship and clinical significance of Her-2 ALDH1 in breast cancer.Methods We selected cancer tissue specimens from 105 of patients with breast cancer used in this study.Her-2,ALDH1 protein expressions were detected by immunohistochemistry and performed statistical analysis.Results（1）Her-2 and ALDH1 positivity in breast cancer was 29.52%,66.67% respectively.（2）HER2 expression was positively correlated with the tumor size and ER expression（P≤0.05）,no correlation with age,nationality,histologic stages and pathological types（P≤0.05）.this study did not found a correlation between ALDH1 and age,nationality,histologic stages,pathological types,tumor size,lymph node metastasis,ER or PR（P0.05）.（3）Expression of Her-2 and ALDH1 in breast cancer was positively correlated.（4）2-year disease-free survival rate in Her-2 positive patients was significantly lower than the Her-2 negative patients.no significant statistical difference observed in 2-year disease-free survival rate from ALDH1 positive or negative breast cancer patients（P0.05）.（5）Results of the analysis of COX regression model revealed Her-2 as a independent factor to indicate the poor prognosis in patients with breast cancer（P=0.008,RR=6.284）.Conclusion The expression of Her-2 and ALDH1 was significantly correlated in patients with Her-2 positive breast cancer.

关 键 词：乳腺癌 乳腺癌干细胞 HER-2 ALDH1免疫组织化学 

分 类 号：S858.292[农业科学—临床兽医学]