类风湿关节炎的T细胞疫苗研究现状  

T-cell Vaccination in Rheumatoid Arthritis

作　　者：张静波[1] 张黎[2] 聂英坤[1] 孔德军[1] 李秀[1] 

机构地区：[1]哈尔滨医科大学附属第二医院风湿免疫科,黑龙江哈尔滨150086 [2]哈尔滨市第一医院胸心外科,黑龙江哈尔滨150010

出　　处：《现代生物医学进展》2012年第31期6173-6175,6191,共4页Progress in Modern Biomedicine

摘　　要：类风湿关节炎是一种可导致关节畸形并丧失功能的慢性自身免疫性疾病。大量研究证实T细胞介导的免疫异常在类风湿关节炎的发病过程中发挥重要作用。经研究证实T细胞疫苗对类风湿关节炎有一定疗效,但受主要组织相容性抗原(MHC)限制,难以应用于临床。最近的T细胞疫苗研究另辟途径,证明在没有发现致病自身抗原的情况下T细胞疫苗依然有可能应用与类风湿关节炎的治疗,为研究类风湿关节炎的发病机制及治疗提供了有益的思路及资料。Rheumatoid arthritis （RA） is a chronic autoimmunity disease that Can cause joint damage and disability. Evidence suggests that RA is a T-cell-mediated autoimmune disease. Accumulating evidence suggests that T cell vaccination（TCV） is effective for treating rheumatoid arthritis. But TCV was hard to use in clinical application because the restriction of major histocompatibility complex （MHC）. The latest researches have proven the feasibily that TCV could apply to RA and have reliable therapeutic effect, even though the autoantigens relevant to RA are unknown.The latest researches also have shown helpful thinking and documents by methods different fi＇om before.

关 键 词：类风湿关节 T细胞 疫苗 

分 类 号：R593.22[医药卫生—内科学]