Tools for Protein Structure Prediction at the bri-shur.com Web Portal  

作　　者：Sergey Feranchuk Ulyana Potapova Vladimir Potapov Dmitry Mukha Vladimir Nikolaev Sergei Belikov 

机构地区：[1]Met. Ltd., Minsk, Kiseliova 20, Belarus [2]Limnological Instiute SB RAS, Irkutsk 664033, Russia [3]Institute of Bioorganic Chemistry NAS Belarus, Minsk 220141, Belarus [4]Belozersky Institute of Physico-Chemical Biology, Moscow 119992, Russia

出　　处：《Journal of Life Sciences》2012年第10期1174-1179,共6页生命科学（英文版）

摘　　要：lntemet services on bioinformatics still remain a popular tool for the researchers. Here the authors present a recently developed web-site http：//bri-shur.com where several tools and pipelines for protein structure prediction are implemented. The prediction of a structure for a particular protein often requires a sensitive and iterative approach, and the web-site provides an environment for this kind of work. Software that is used in the services includes both free programs available in the Internet and newly developed algorithms. The service on homology screening in PDB for a structure template is implemented using an approach that is alternative to well-known BLAST algorithm and it has some advantages over BLAST. The service on homology modeling uses well-known Nest program. The service on protein energy estimate allows selecting a best template in the set of homologs and adds a functionality of fold recognition to the environment. The design of the site simplifies several of the most useful bioinformatics routines, thus making them available to a large community of researchers. Services are provided free of charge without registration, and the user＇s privacy is taken care of.

关 键 词：Web-service SOAP homology modeling homology screening protein folding. 

分 类 号：TP393.4[自动化与计算机技术—计算机应用技术] O6-0[自动化与计算机技术—计算机科学与技术]