Differential regulation of cPLA2 and iPLA2 expression in the brain  

作　　者：Kazuhiro TANAKA Nikhat J. SIDDIQI Abdullah S. ALHOMIDA Akhlaq A. FAROOQUI Wei-Yi ONG 

机构地区：[1]Neurobiology and Ageing Research Programme, National University of Singapore, Singapore 117456, Singapore [2]Department of Biochemistry, College of Science, King Saud University, Riyadh, 1145,1 Saudi Arabia [3]Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus OH 43210, USA [4]Department of Anatomy, National University of Singapore, Singapore 119260, Singapore

出　　处：《Frontiers in Biology》2012年第6期514-521,共8页生物学前沿（英文版）

摘　　要：The phospholipase A2 （PLA2） family members arc critical regulators of membrane structure and lipid composition and have been implicated in neuroinflammation, oxidative stress and neurodegeneration. Here, we review the published data describing regulation of cPLA2 and iPLA2 gene expression. Based on promoter sequence, cPLA2 expression can be regulated by glucocorticoid and pro-inflammatory cytokines, whereas transcription of iPLA2 can be controlled in response to sterol level. RNA degradation in 3＇ UTR and epigenetic mechanisms may be involved in the regulation of cPLA2 and iPLA2 expression, respectively. MicroRNA target sequences lie within cPLA2 and iPLA2 mRNAs. Together, these findings indicate differential regulation of cPLA2 and iPLA2 expression. It is hoped that determination of diverse regulatory mechanisms of the PLA2 family may open new doors for development of novel therapeutic compounds that modulate PLA2 expression and function in the treatment of brain diseases.The phospholipase A2 （PLA2） family members arc critical regulators of membrane structure and lipid composition and have been implicated in neuroinflammation, oxidative stress and neurodegeneration. Here, we review the published data describing regulation of cPLA2 and iPLA2 gene expression. Based on promoter sequence, cPLA2 expression can be regulated by glucocorticoid and pro-inflammatory cytokines, whereas transcription of iPLA2 can be controlled in response to sterol level. RNA degradation in 3＇ UTR and epigenetic mechanisms may be involved in the regulation of cPLA2 and iPLA2 expression, respectively. MicroRNA target sequences lie within cPLA2 and iPLA2 mRNAs. Together, these findings indicate differential regulation of cPLA2 and iPLA2 expression. It is hoped that determination of diverse regulatory mechanisms of the PLA2 family may open new doors for development of novel therapeutic compounds that modulate PLA2 expression and function in the treatment of brain diseases.

关 键 词：phospholipase A2 transcriptional regulation single nucleotide polymorphism MIRNA 

分 类 号：Q959.620.6[生物学—动物学] O172.1[理学—数学]