颈动脉斑块超声造影特征与脑梗死及血清hs-CRP相关研究  

Study on the Relationship Between the Ultrasonic Feature of Carotid Plaques and Cerebral Infarction and Serum High Sensitive C-reactive Protein Lever

作　　者：温慧丽[1] 

机构地区：[1]鄂尔多斯市中心医院神经内科,内蒙古东胜017000

出　　处：《内蒙古医学杂志》2012年第8期900-904,共5页Inner Mongolia Medical Journal

摘　　要：目的:探讨颈动脉斑块内新生血管实时超声造影的显像特征及血清超敏C反应蛋白(high sensitive c-reactive protein,hs-CRP)水平对脑梗死事件的预测作用。方法:对80例脑梗死伴颈动脉粥样硬化患者的80处斑块行超声造影,根据斑块的回声特征,将其分为软斑块组、混合斑块组及硬斑块组,比较3组间的脑梗死率、hs-CRP水平及斑块内造影剂增强持续时间的差异,并分析斑块内造影剂增强持续时间与血清hs-CRP水平的相关性。常规对患者行头颅CT或MRI检查,确诊脑梗死事件。结果:软斑组及混合斑组脑梗死率、hs-CRP水平及斑块内造影剂增强持续时间显著高于硬斑组,差异有统计学意义(P<0.01),脑梗死组hs-CRP水平显著高于非脑梗死组,差异有统计学意义(P<0.01),斑块内造影剂增强持续时间与血清hs-CRP水平呈高度正相关,相关系数为0.718。结论:斑块的类型与斑块内新生血管的形成及血清hs-CRP水平有关,对其关系的研究有助于评价斑块的稳定性,并指导临床预防脑梗死事件的发生。Objective：To Study the relationship between the neovascularization of carotid atherosclerotic plaques by real-time contrast-enhanced ultrasonography（CEUS）and cerebral infarction and serum high sensitive c-reactive protein（hs-CRP）lever.Methods：Eighty cases with eighty carotid atherosclerotic plaques were examined by real-time CEUS.According to the imagine performance,the cases were divided into three groups：soft plaques group,mixed plaques group and hard plaques group.The differences of the incidence rate of cerebral infarction events,serum hs-CRP lever and enhancement persistent time of contrast media in plaques by real-time CEUS,were analysed among the three groups.The cerebral infarction events were diagnosed by CT or MRI routinely.Results：The incidence rate of cerebral infarction events,serum hs-CRP lever and enhancement persistent time of contrast media in soft plaques group and mixed plaques group were significantly high than that in hard plaques group The risk of cerebral infarction was higher in the patients with elevated level of hs-CRP.It showed positive correction between the enhancement persistent time of contrast media and serum hs-CRP lever,and the correlation coefficient was 0.718.Conclusions：The type of the plaque is correlated with the neovascularization of plaques and serum hs-CRP lever.The study of relationships among them can help to evaluate stability of plaques and guide the clinician to prevent the incidence of cerebral infarction events.

关 键 词：超声检查 造影剂 颈动脉粥样硬化斑块 超敏C反应蛋白 脑梗死 

分 类 号：R814.43[医药卫生—影像医学与核医学] R743.33[医药卫生—放射医学]