2011年度慈溪市儿童手足口病病原学特征分析  

Etiological diagnosis and analysis of children hand-foot-mouth disease in Cixi in 2011

作　　者：岑迪[1,2] 吴建根[2] 罗莹[2] 王四全[2] 

机构地区：[1]浙江大学公共卫生学院,浙江杭州310058 [2]慈溪市疾病预防控制中心,浙江慈溪315300

出　　处：《中国儿童保健杂志》2012年第12期1109-1112,共4页Chinese Journal of Child Health Care

摘　　要：【目的】研究2011年慈溪市儿童手足口病(hand-foot-mouth disease,HFMD)病原学特征,了解本地区HFMD流行趋势。【方法】收集监测哨点医院上送的临床诊断为HFMD病例标本,应用实时荧光(Real-time)RT-PCR法检测标本中的人肠道病毒(HEV)、肠道病毒71型(EV71)和柯萨奇病毒A组16型(CVA16)特异性核酸。【结果】289例标本中检出总肠道病毒阳性病例260例(89.97%),其中EV71占总阳性率的58.46%,CVA16占总阳性率的22.31%,肠道其他型19.23%;病例年龄集中在1～5岁;男女性阳性比例为1.49∶1;住院病例EV71阳性率为68.97%。【结论】EV71和CVA16为本地手足口病的主要病原体,EV71是引起重症和住院病例的优势毒株型,在局部区域内CVA16型占主导。[Objective] To study the pathogenic characterization of the hand-foot-mouth diseases （HFMD） in Cixi in 2011,and to understood the HFMD epidemic trend. [Method] Sentinel hospital surveillance for clinical diagnosis of HFMD case specimens were collected. Real-time fluorescence（Real-time） RT-PCR assay was used to detect human enteric viruses （HEV）,enterovirus 71 （EV71）and Coxsackie virus group A type 16 （CVA16） of specific nucleic acid. [Results] Positive rate of total intestinal virus specimen was 89.97% in 289 cases; Enterovirus 71 and Coxsackie A16 were 58.46% and 22.31% respectively,other type accounted for 19.23 %. High positive rate was found in 1 ~ 5 years old and male chil- dren patients; EV71 positive rate of hospitalized cases was 68. 97%. [Conclusion] EV71 and CVA16 are the major pathogens of HFMD in Cixi,EV71 infection is much likely to cause severe cases and inpatients,in some area CVA16 is the dominant species.

关 键 词：手足口病 病原学 肠道病毒71型 柯萨奇A16型 儿童 

分 类 号：R725.1[医药卫生—儿科]