不同种类小剂量性激素对绝经早期妇女生活质量和血液生化的影响  

Effects of different low-dose regimens of hormone therapy on quality of life and blood biochemistry in early postmenopausal women

作　　者：冯春梅[1] 王春红[2] 孙志刚[1] 

机构地区：[1]牡丹江医学院生物技术实验室,黑龙江牡丹江157011 [2]沈阳医学院公共卫生学院,辽宁沈阳121400

出　　处：《中国现代医生》2012年第36期33-35,共3页China Modern Doctor

基　　金：沈阳医学院科技基金项目(20112059)

摘　　要：目的比较使用不同种类小剂量激素对绝经早期妇女生活质量及血液生化的影响。方法牡丹江医学院红旗医院于2010年5月～2011年5月选择绝经早期并有绝经症状的患者100例,随机分为A组50例(戊酸雌二醇片1 mg/d+安宫黄体酮2 mg/d)和B组50例(利维爱1.25 mg/d)。受试者每日服钙剂一次,共6个月,比较A、B两组用药前后的绝经症状和血液生化指标的变化。结果两组治疗前后绝经症状评分显著下降(P<0.05),但组间比较差异无统计学意义(P>0.05)。对血液生化的影响未见明显异常,偶见高密度脂蛋白C升高和血小板轻度降低。结论使用小剂量性激素治疗6个月对绝经早期妇女的生活质量有一定程度的改善作用。Objective To compare the effects of different low-dose regimens of hormone therapy （HT） in early postmenopausal women about quality of life and blood biochemical. Methods Applied 100 early postmenopausal women between May 2010 to May 2011 with apparent perimenopausal syndrome symptoms were assigned into two groups. Group A：50 cases （Estra- diolvalerate 1 mg/d＋medroxyprogesterone acetate 2 mg/d） ;Group B：50 cases （Tibolone 1.25 mg/d）. The subjects took calcium once a day by 6 months and compared the changes of each group of clinical symptoms and blood biochemical before and after treatment. Results The Kupperman scores of groups with before and after treatment decreased significantly （P 〈 0.05）, and the comparison between groups had no statistically significant difference （P 〉 0.05）. The blood biochemical showed no obvious adverse effects excepting elevated HDL-C and the platelet slight decrease. Conclusion The small.dose hormone therapy by six months which can be improved to early postmenopausal women＇s quality of life in some extent.

关 键 词：小剂量性激素 绝经后妇女 生活质量 血液生化 

分 类 号：R711-75[医药卫生—妇产科学]