宏基因组学与道地药材研究  

Study on metagenomics and genuine traditional Chinese medicinal materials

作　　者：陈晓辰[1] 宋经元[1] 董林林[1] 姚辉[1] 陈士林[1] 韩建萍[1] 

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所,北京100193

出　　处：《中草药》2012年第12期2315-2320,共6页Chinese Traditional and Herbal Drugs

摘　　要：宏基因组学是将分子生物学技术应用于微生物基因总和研究的一门新兴学科,现已广泛应用于医药、农业、海洋生态环境、土壤生态环境等领域。道地药材凭借其质优、疗效好的优势自古以来被各医家所青睐,其形成与诸多因素有关,其中根际微环境在药用植物次生代谢产物形成中起着重要作用。着重介绍宏基因组学的概念、技术策略以及其在道地药材研究中的应用现状,进一步阐明土壤微生物对道地药材形成机制的影响,并为解决药用植物连作障碍提出新的研究思路。Metagenomics is a newly developing discipline which applies molecular biological techniques to analyze genomes of the total microbiota.Metagenomics is widely used in various fields,such as medicine,agriculture,marine ecological environment,soil ecological environment.Resorting to its excellent quality and good efficacy,genuine traditional Chinese medicinal materials（TCMM） have been in good graces of many physicians.The geoherbalism formation of TCMM is based on many factors among which the microenvironment of rhizosphere soil plays a important role in formation of secondary metabolism in medicinal plants.This article emphasizes on illustrating the conception,technique,and strategy of metagenomics and its potential application in genuine TCMM and provides new insights in removing the continuous cropping obstacles in medicinal plants.

关 键 词：宏基因组学 根际土壤 道地药材 微环境 连作障碍 

分 类 号：R282.1[医药卫生—中药学]