电导率法筛选陈皮油微乳处方  

Prescription screening of tangerine peel oil microemulsion by conductivity method

作　　者：李凌绪[1] 张相飞[1] 程艳静[1] 

机构地区：[1]青岛农业大学化学与药学院,山东青岛266109

出　　处：《中草药》2012年第12期2396-2400,共5页Chinese Traditional and Herbal Drugs

基　　金：山东省自然科学基金资助项目(2010ZRCQ026)

摘　　要：目的筛选陈皮油微乳处方并考察其性质。方法在37℃恒温水浴下,滴水法制备微乳,通过测量体系的电导率,确定相变临界点,绘制伪三元相图,筛选最优空白微乳处方,并制备陈皮油微乳。考察制剂形态、柠檬烯质量浓度、分散相形态及粒径、制剂稳定性等。结果以油酸乙酯为油相、HEL-40为乳化剂、甘油为助乳化剂,以Km值为2的空白微乳处方最佳。陈皮油微乳中柠檬烯为(3 208.67±123.62)mg/L,分散近似球形,平均粒径为(56.5±4.1)nm。结论所制备的陈皮油微乳粒径小、分布均匀、性质稳定。Objective To screen the prescription of tangerine peel oil（TPO） microemulsion and to investigate it’s characteristics.Methods Under 37 ℃,the electrical conductivity was employed to determine the critical point of phase change and dropping water method was applied to drawing the pseudo-ternary phase diagrams by which the best prescription of blank microemulsion was screened,and then the TPO microemulsion was prepared.The form,content of limonene,shape and particle size of the dispersed phase,and the stability of prepared microemulsion were investigated.Results The best prescription was as follows： ethyl oleate was selected as oil phase,HEL-40 as emulsifier,glycerine as cosurfactants,Km = 2,and oil-mixed emulsifier（2∶8）.The total content of limonene in TPO microemulsion was（3 208.67 ± 123.62） mg/L,the shape of dispersed phase was nearly spherical,and the mean diameter of particles was（56.5 ± 4.1） nm.Conclusion The prepared TPO microemulsion is stable with small size and uniform distribution.

关 键 词：陈皮油 伪三元相图 微乳 电导率 柠檬烯 

分 类 号：R283.6[医药卫生—中药学]