Digoxin intoxication： An old enemy in modern era  

作　　者：Bahadir Kirilmaz Serkan Saygi Hasan Gungor Ugur Onsel Turk Emin Alioglu Serdar Akyuz Fatih Asgun Istemihan Tengiz Ertugrul Ercan 

机构地区：[1]Department of Cardiology, Canakkale Onsekiz Mart University, Medical Faculty, Canakkale 17100, Turkey [2]Department of Cardiology, Odemis State Hospital, Izmir 35750, Turkey [3]Department of Cardiology, Central Hospital, Izmir 35580, Turkey [4]Department of Cardiology, Yunus Emre State Hospital, Eskisehir 26190, Turkey [5]Department of Cardiovascular Surgery, Canakkale Onsekiz Mart University, Medical Faculty, Canakkale 17100, Turkey

出　　处：《Journal of Geriatric Cardiology》2012年第3期237-242,共6页老年心脏病学杂志（英文版）

摘　　要：Objectives Although development of new treatment modalities limited digoxin usage, digoxin intoxication is still an important issue which could be easily overlooked. In this report, we analyzed a case series definitively diagnosed as digoxin intoxication in the modern era. Methods We analyzed 71 patients hospitalized with digoxin intoxication confirmed by history, complaints, clinical and electrocardiograph （ECG） findings, and serum digoxin levels 〉 2.0 ng/mL, during a five year period. The demographic and clinical data, indications for digoxin use, digoxin dosage, concurrent medications, laboratory data, hospital monitoring, and ECG findings were obtained from all patients. Results Thirty-eight of 71 patients （53.5%） had symptoms of heart failure during admission or later. Sixty-four percent of patients were older than 75 years. The percentage of females was 67%. Atrial fibrillation, hypertension and gastrointestinal complaints were more frequent in the females （64% in females, 30% in males, P = 0.007; 81% in female, 52% in males, P = 0.01; 50% in female, 17.3% in males, P = 0.008, respectively）. The mortality rate during the hospital course was 7%. Conclusions This report demonstrated the reduced mortality rates in patients with digoxin intoxication over the study period. Gastrointestinal complaints are the most common symptoms in this population.

关 键 词：Digoxin intoxication DIGITALIS Heart failure ARRHYTHMIA 

分 类 号：S858.316.9[农业科学—临床兽医学] Q78[农业科学—兽医学]