四黄降糖颗粒对胰岛素抵抗模型大鼠降糖作用的研究  

Hypoglycemic effects of the Sihuang Gypoglycemic Granule(SHHG) on the rat model of insulin resistance

作　　者：王永刚[1,2] 尤金枝[3] 尚俊平[1,2] 齐婧[3] 于远望[1] 郑刚[1,2] 杨景锋[1] 

机构地区：[1]陕西中医学院心脑血管病研究所,陕西咸阳712000 [2]陕西中医学院第二附属医院心脑血管病中心,陕西咸阳712000 [3]陕西中医学院

出　　处：《湖南中医药大学学报》2012年第11期16-18,30,共4页Journal of Hunan University of Chinese Medicine

基　　金：国家自然科学基金项目(30973830;30901895);陕西省教育厅项目(09JK408);陕西省"13115"科技创新工程重大科技专项(2009ZDKG-78);陕西省第五批重点专科心脑血管病科和陕西省第六批重点专科糖尿病科资助项目

摘　　要：目的研究四黄降糖颗粒(Si-haung Hypoglycemic Granule,SHHG)对胰岛素抵抗模型大鼠的降糖作用。方法采用高脂饲料加地塞米松法建立实验性胰岛素抵抗大鼠模型,观察灌胃给药1个月后大鼠血中的胰岛素(Ins)和葡萄糖水平(FBG),以及血清甘油三酯(TG)、血浆总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、C反应蛋白(CRP)变化。结果与正常组比较,模型组Ins、FBG、CRP、TG、TC、LDL-C均明显升高,差异具有统计学意义(P<0.05);与模型组比较,罗格列酮组、SHHG组Ins、FBG、CRP、TG、TC、LDL均明显降低,差异具有统计学意义(P<0.05)。罗格列酮组与SHHG组比较无显著性差异(P>0.05)。结论四黄降糖颗粒能明显降低Ins、FBG、hs-CRP、TG、TC、LDL-C的水平,具有一定的增强胰岛素敏感性和改善胰岛素抵抗的作用。Objective To study the hypoglyeemie ef/eets of the Sihaung Hypoglyeemie Granule （SHHG） on rat model of insulin resistance. Methods The diabetic rat model was established by feeding high fat diet for a certain duration and intraperitoneal injection with Dexamethasone（DEX） （1 mg/kg） every other day. The fast blood glucose,total cholesterol （TC）, low-density lipopro- rein eholesterol（LDL-C）, high-density lipoprotein eholesterol（HDL-C）, C-reactive protein （hs-CRP） and insulin content in bloods of these rats were evaluated after gastric lavaged with medicine for one month. Results Compared with control group, the contents of Ins, FBG, TG, TC, LDL-C andCRP in model group were significantly reduced（P〈0.05）. Compared with model group, the contents of Ins, FBG ,TG,TC, LDL-C and CRP in SHHG group and rosiglitazone hydrochloride group were significantly reduced （P〈O.05）. But there were no significant difference between them. Conclusion SHHG can significantly reduce the contents of Ins, FBG, TG, TC, LDL-C and CRP, and enhance the sensitivity to insulin and improve insulin resistance.

关 键 词：胰岛素抵抗 四黄降糖颗粒 降糖作用 大鼠 黄芪 生地黄 大黄 黄连 

分 类 号：R285.5[医药卫生—中药学]