大学生谷草转氨酶和谷丙转氨酶的比值与代谢综合征相关性研究  

Relationship between aspartate aminotransferase to alanine aminotransferase ratio and metabolic syndrome in college students

作　　者：刘晓丽[1] 陆强[1] 焦俊凤[2] 王晓明[1] 马春明[1] 谢长顺[3] 尹福在[1] 

机构地区：[1]河北省秦皇岛市第一医院内分泌科,066000 [2]河北省秦皇岛市第一医院体检中心,066000 [3]河北省秦皇岛市第一医院消化科,066000

出　　处：《中华健康管理学杂志》2012年第6期409-412,共4页Chinese Journal of Health Management

摘　　要：目的探讨大学生谷草转氨酶（AST）／谷丙转氨酶（ALT）比值和代谢综合征（MS）之间的关系。方法通过分层整群随机抽样的方法，选取秦皇岛市425名19—24岁大学生（男性216例，女性209例）作为研究对象，测量人体基本参数和空腹血糖（FPG）、血三酰甘油（TG）、高密度脂蛋白胆固醇（HDL—C）、ALT、AST及真胰岛素（TI）等代谢相关指标。按AST／ALT比值分为AST／ALT比值〈1组和AST／ALT比值≥1组。MS诊断参考ATPⅢ标准。结果检测出AST／ALT比值〈1者146例（34．4％），调整年龄和性别后，AST／ALT比值与HDL-C呈正相关（r=0．125），与体重指数（BMI）（r=-0．281），腰围（WC）（r=-0．264），TG（r=-0．134），TI（r=-0．118）和胰岛素抵抗指数（HOMA—IR）（r=-0．121）呈负相关（P〈0．05）。MS患病率为2．1％，男性和女性相似（2．3％和1．9％，X2=0．082，P=0．774）。AST／ALT比值〈1组Ms检出率明显高于AST／ALT比值≥1组（4．8％ vs．0．7％，P=0．016）。调整年龄，性别和BMI后，大学生AST／ALT比值〈1组MS检出率为AST／ALT比值≥1组的6．975倍（95％CI：1．430～34．019，P=0．016）。结论大学生AST／ALT比值与代谢综合征显著相关。Objective To evaluate the relationship between aspartate aminotransferase to alanine aminotransferase ratio （AST/ALT ratio ） and metabolic syndrome in college students. Methods Anthropometric and metabolic measurements including fasting plasma glucose （ FPG ）, triglyceride （ TG ）, high-density lipoprotein cholesterol （HDL-C）, true insulin （TI）, （AST and ALT） were assessed in a cross- sectional study of 425 college students aged 19 to 24 years old （ male 216, female 209 ） in 2009. The participants were then assigned to the AST/ALT ratio 〈 1 group or the AST/ALT ratio ≥ 1 group. Metabolic syndrome was defined as Adult Treatment Panel Ⅲ criteria. Results AST/ALT ratio 〈 1 was found in 146 subjects （34. 4% ）. After adjustment for age and sex, AST/ALT ratio showed a positive correlation with HDL- C （r=0. 125） and negative correlations with body mass index （BMI, r= -0. 281 ）, waist circumtance （WC,r = -0. 264）,TG （r= -0. 134）,TI （r= -0. 118） and HOMA-insulin resistance （HOMA-IR,r = - 0. 121 ） （ all P 〈 0. 05 ）. The prevalence of metabolic syndrome was 2. 1% and was similar in males and females （2. 3% vs. 1.9% ,P =0. 774）. Those with AST/ALT ratio 〈 1 had a significantly higher prevalence of metabolic syndrome （ 4. 8% vs. O. 7% , P = 0. 016 ） . After adjustment for age, gender and BMI, the prevalence of metabolic syndrome of subjects with AST/ALT ratio 〈 1 was nearly 7 （ 95% CI： 1. 430 to 34. 019 ,P = 0. 016） times of those with AST/ALT ratio ~〉 1. Conclusion AST/ALT ratio may be related with metabolic syndrome in college students.

关 键 词：代谢综合征X 肥胖症 胰岛素 

分 类 号：R589[医药卫生—内分泌]