葡萄糖转运蛋白4功能调节信号通路及其在药物研发中的应用  

The signaling pathway for regulation of glucose transporter 4 and its application in drug development

作　　者：汤璇[1] 陈静[1] 沈旭[1] 

机构地区：[1]中国科学院上海药物研究所,上海201203

出　　处：《中国科学：化学》2012年第12期1760-1773,共14页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金项目(91213306;21021063;81173105)资助

摘　　要：葡萄糖转运蛋白4(glucose transporter 4,GLUT4)是胰岛素响应组织骨骼肌和脂肪组织内负责葡萄糖吸收的转运蛋白,它与生物体糖代谢过程密切相关.在肥胖或以胰岛素抵抗为特征的2型糖尿病等代谢性疾病中,GLUT4功能受损;反之,GLUT4功能的变化也能影响整体的糖代谢水平.本文概述了GLUT4的功能、组织分布、功能调节方式以及调控GLUT4功能的小分子化合物的研究进展,讨论了GLUT4在其他疾病中的应用,并展望了其未来研究方向.Glucose transporter 4（GLUT4） as a mediator for glucose up-take in skeletal muscle and adipose tissue plays important roles in whole-body glucose metabolism.Impaired glucose disposal is always observed in metabolic disease（such as obesity and type 2 diabetes）,and glucose homeostasis can be impacted by alteration of GLUT4 function.Here,we summarize the function,tissue distribution and regulation pathway of GLUT4,and highlight the chemicals in restoring glucose homeostasis via modulating GLUT4 function.Finally,we also discuss the possible research focus of GLUT4 in the future and the association of GLUT4 with other diseases.

关 键 词：葡萄糖转运蛋白4(GLUT4) 胰岛素 糖尿病 葡萄糖转运蛋白膜转位 

分 类 号：R587.1[医药卫生—内分泌]