羟乙基淀粉200/0.5氯化钠注射液在创伤失血性休克患者中的应用  

Application of hydroxyethyl starch 200/0.5 and sodium chloride injection in trauma patients with hemorrhagic shock

作　　者：陆萍[1] 刘春晓[1] 王秀丽[1] 

机构地区：[1]河北医科大学第三医院麻醉科,石家庄050051

出　　处：《疑难病杂志》2012年第12期931-933,共3页Chinese Journal of Difficult and Complicated Cases

基　　金：河北省卫生厅重点学科跟踪项目(No.GL2011-46)

摘　　要：目的观察羟乙基淀粉200/0.5氯化钠注射液在创伤失血性休克患者中的临床应用效果。方法按照临床诊断标准,选取中重度失血性休克患者78例,随机分为2组:对照组和研究组各39例。2组患者分别输注聚明胶肽和羟乙基淀粉200/0.5氯化钠注射液1000 ml,测定液体输注前后患者血压、脉搏、休克指数、Na^+、CI^-、SpO_2等指标变化。结果与人室时比较,2组输注液体20～30 min后血压均明显升高(P<0.05),而休克指数均显著降低(对照组20 min除外),差异有统计学意义(P<0.05),且研究组优于对照组(P<0.05)。治疗后2组血钠、血氯均升高(P<0.05),但仍在正常范围,SpO_2均显著升高(P<0.05),且研究组优于对照组(P<0.05)。结论输注羟乙基淀粉200/0.5氯化钠注射液可有效改善失血性休克患者血压,纠正休克。Objective To observe the clinical effect of hydroxyethyl starch 200/0.5 and sodium chloride injection in trauma patients with hemorrhagic shock.Methods According to the clinical diagnostic criteria,seventy eight patients with moderate or severe hemorrhagic shock were randomly divided into two groups：control group and study group.Each group was infused of polygeline or hydroxyethyl starch 200/0.5 sodium chloride injection 1000 ml respectively.Blood pressure（BP）, pulse（P）,shock index（SI）,Na＋,C1~,SpO,and other indicators before and after the fluid infusion were determined.Results Compared with the time point when entering operation room,BP was significantly increased（P 0.05）,SI was significandy lowered（except 20 min in control group,P 0.05） and others had no significant change（P 0.05） in both groups 20～30 minutes after infusion,it was superior in study group than control group（P 0.05 ）.Conclusion Infusion of hydroxyethyl starch 200/0.5 and sodium chloride injection can effectively improve BP and correct the shock in hemorrhagic shock patients.

关 键 词：羟乙基淀粉200 0 5 休克 失血性 创伤 血压 

分 类 号：R614[医药卫生—麻醉学]