3-氯-4-二氯甲基-5-羟基-2(5氢)-呋喃酮对大鼠的遗传毒性以及脂质过氧化作用的影响  

Genotoxic Effect of 3-Chloro-4-(Dichloromethyl)-5-Hydroxy-2(5H)-Furanone and Its Influence on Lipid Peroxidation on Rats

作　　者：鲁文清[1] 谢虹[1] 李晓燕[1] 越飞[1] 甘起霓[1] 陈秀娜[1] 

机构地区：[1]同济医科大学环境卫生学教研室,武汉430030

出　　处：《中国公共卫生》2000年第1期19-20,共2页Chinese Journal of Public Health

基　　金：国家教委留学回国人员启动基金

摘　　要：采用灌胃方法，用３氯４（ 二氯甲基）５羟基２（５氢）呋喃酮（ ＭＸ） 染毒Ｗｉｓｔａｒ 大鼠（１－６５ 、１６５ 、１６５００ｎｇ ＭＸ／ｋｇ），每天１ 次，连续１５ 天。结果发现，一定剂量的ＭＸ可使大鼠精子畸形率明显增高，使肝、肾脏器系数发生改变，并出现病理变化，但对大鼠骨髓嗜多染红细胞（ＰＣＥｓ） 微核的诱导和大鼠血清、组织（ 肝、肾、睾丸） 脂质过氧化（ＬＰＯ） 水平无明显影响。提示ＭＸ对大鼠生殖细胞具有遗传毒性，对肝肾有损伤作用，但不产生氧化性损伤，骨髓细胞似乎对ＭＸ的遗传毒性作用不敏感。chloro 4 (dichloromethyl) 5 hydroxy 2(5H) furanone(MX)was administerd to Wistar rats (1.65,165,16500 ng/kg) by gavage one time a day for 15 days.At the end of this period,significant increases of sperm abnormality rate were observed in rats exposed MX at certain doses.Organ index of liver and kidney were changed and pathological changes took place.No signficant increases of micronucleus induction in polychromatic erythrocytes(PCEs) of bone marrow and lipid peroxidation(LPO) level in serum and tissue(live,kidney and testicle)of rats were showed.Our results suggested that MX was able to induce genotoxicity of reproductive cells and to injure the liver and kidney of rats exposed.But no oxidative damage was found.

关 键 词：MX 微核 精子畸形 LPO 遗传毒性 呋喃酮 

分 类 号：R996[医药卫生—毒理学]