复方精油对D-半乳糖衰老模型小鼠的抗衰老作用  

Anti-Aging Function of the Blended Essential Oil in Murine Aging Model Induced by Galactose

作　　者：黄玲玲[1] 魏道智[1] 吴亚妮[2] 姚雷[2] 

机构地区：[1]福建农林大学生命科学学院,福州350002 [2]上海交通大学农业与生物学院,上海200240

出　　处：《上海交通大学学报（农业科学版）》2012年第6期32-35,共4页Journal of Shanghai Jiaotong University(Agricultural Science)

基　　金：上海市绿化和市容管理局重大项目(G102407);上海市科委重大攻关项目(10DZ1200403);公益性行业(农业)科研专项经费(200903056)

摘　　要：探讨复方精油对D-半乳糖衰老模型小鼠的抗衰老作用。通过皮下注射D-半乳糖制备小鼠衰老模型,同时小鼠背部脱毛并连续涂抹3个不同浓度的复方精油42d,取小鼠血清及涂药处皮肤检测超氧化物歧化酶(SOD)的活性和丙二醛(MDA)含量,同时检测皮肤中羟脯氨酸(HYP)含量。结果表明,与模型组比较,高中低浓度复方精油组小鼠血清中SOD活性提高14.94%～20.27%(P<0.01),MDA含量降低17.00%～26.30%(P<0.01或P<0.05);皮肤中SOD活性升高58.00%～61.11%(P<0.01),MDA含量降低12.23%～26.04%(P<0.01),HYP含量升高33.70%～140.70%(P<0.01)。该复方精油具有良好的抗氧化、抗衰老作用,具有潜在的开发应用价值。To investigate the anti-aging function of the blended essential oil in murine aging model, mice were injected subcutaneously with D-galactose and the blended essential oil with 3 different concentrations was applied by smearing the mixture on the naked back skin of the mice for 42 days. The serum and skin specimen were collected to determine the activity of superoxide dismutase （SOD）, the content of malondialdehyde （MDA） and hydroxyproline （HYP）. The results showed that, compared with model group without treatment of essential oil, the SOD activity in the serum of the three groups treated with high, medium and low dose of blended essential oil was significantly improved by 14.94%-20.27 % （P〈0.01） and the MDA content was decreased by 17.00%--26. 30% （P〈0. 01 or P〈0. 05）. In the skin specimen,on the other hand, the activity of SOD was elevated by 58. 00%-61. 11% （P〈0. 01） and the content of MDA decreased by 12.23%-26.04% （P〈0.01） while the HYP level was increased 33.70%- 140.70 % （P〈0. 01）. In conclusion, the blended essential oil possesses satisfying function of anti-oxidation and anti-aging, indicating potential usage in the future.

关 键 词：复方精油 抗衰老 超氧化物歧化酶(SOD) 丙二醛(MDA) 羟脯氨酸(HYP) 

分 类 号：R285.5[医药卫生—中药学]