恶性风险指数、超声特征及CA125对上皮性卵巢癌的预测价值  

The predictive values for risk of malignancy index,ultrasound features and CA125 in primary epithelial ovarian carcinomas

作　　者：陈铃[1] 袁颂华[2] 石小红[1] 

机构地区：[1]广东省中医院超声科,广东广州510120 [2]广东省中医院妇科,广东广州510120

出　　处：《暨南大学学报（自然科学与医学版）》2012年第6期633-637,共5页Journal of Jinan University(Natural Science & Medicine Edition)

摘　　要：目的:评价恶性风险指数(RMI)、超声特征及CA125对上皮性卵巢癌预测的临床价值。方法:收集96例经手术和病理确诊的卵巢肿瘤患者的临床资料,其中上皮性卵巢癌52例,卵巢良性肿瘤44例,根据绝经状态、超声积分、肿块大小、CA125水平计算恶性风险指数,对卵巢肿块良恶性进行预测,并计算敏感性、特异性和约登指数。结果:RMI1、RMI2、RMI3界值为200,RMI4界值为450时,判断卵巢恶性肿块的敏感性为58.0%～62.0%、特异性为84.1%～90.9%,YI值为0.50、0.48、0.47、0.51。各RMI之间的诊断效能的差异无显著的统计学意义(P>0.05)。超声积分、CA125、绝经状态及肿块大小四个指标单独诊断卵巢癌的YI值为0.49、0.33、0.31及0.17。但通过计算RMI,可将特异性从77.3%提高到90.9%。结论:RMI是判断上皮性卵巢癌的良好指标,具有较好的临床应用价值,超声仍然是诊断上皮性卵巢癌的首选方法。Aim：Assessment of predictive values of CA125,ultrasound features（US） and risk of malignancy index（RMI） for Primary Epithenal ovarian carcinomas. Methods： This is a retrospective study of 96 women with proved ovarian tumor surgically.Among them,52 cases were primary epithelial ovarian carcinomas,44 cases were benign tumor.The sensitivity,specificity and youden＇s index of menopausal status,serum CA125 level,ultrasound findings,the biggest size of tumor and separately and combined into the RMI to diagnose Primary Epithenal ovarian carcinomas. Results： When the cutoff levels of RMI1,RMI2,RMI3 were set at 200 and RMI4 at 450,the sensitivity for diagnosing malignant adnexal masses ranged 58.0%～62.0%,the specificity ranged 84.1%～90.9%.The Youden＇s indexes（YI） of RMI1,RMI2,RMI3,and RMI4 were 0.50,0.48,0.47,and 0.51,respectively.The difference of RMI1,RMI2,RMI,and RMI4 had no significant difference.The relevant YI of you den＇s index of ultrasound foundings,serum CA-125 level,menopausal status,the biggest size of tumor were 0.31,0.33,0.49and 0.17,respectively.But through the calculation RMI,specific can be increased from 77.3% to 90.9%. Conclusion：RMI is a good indicator for predictive values in the Primary Epithenal ovarian carcinomas,and may be introduced easily into clinical practice.Ultrasound is still the first choice of important method in diagnosis of ovarian carcinomas.

关 键 词：上皮性卵巢癌 恶性风险指数 超声特征 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.31[医药卫生—诊断学]